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    The european particle therapy network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation

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    Authors
    De Roeck, L.
    van der Weide, H. L.
    Eekers, D. B. P.
    Kramer, M. C.
    Alapetite, C.
    Blomstrand, M.
    Burnet, N. G.
    Calugaru, V.
    Coremans, I. E. M.
    Di Perri, D.
    Harrabi, S.
    Iannalfi, A.
    Klaver, Y. L. B.
    Langendijk, J. A.
    Romero, A. M.
    Paulsen, F.
    Roelofs, E.
    de Ruysscher, D.
    Timmermann, B.
    Vitek, P.
    Weber, D. C.
    Whitfield, G. A.
    Nyström, P. W.
    Zindler, J.
    Troost, E. G. C.
    Lambrecht, M.
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    Affiliation
    KU Leuven - University of Leuven, Department of Oncology - Laboratory of Experimental Radiotherapy, Belgium; University Hospitals Leuven, Department of Radiation Oncology, Belgium. Electronic address: Laurien.deroeck@uzleuven.be. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands. Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Maastricht, The Netherlands. Institut Curie, Radiation Oncology Department, Paris & Proton Center, Orsay, France. Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden. The Christie NHS Foundation Trust, Manchester, United Kingdom. Institute Curie, Paris, France; Institute Curie, Centre de Protonthérapie d'Orsay, Orsay, France. Leiden University Medical Centre, Department of Radiotherapy, Leiden, The Netherlands; Holland Proton Therapy Centre, Delft, The Netherlands. Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Particle Therapy Interuniversitary Center Leuven (PartICLe), Belgium. Heidelberg Ion-Beam Therapy Centre (HIT), Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany. National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy. Holland Proton Therapy Centre, Delft, The Netherlands. Holland Proton Therapy Centre, Delft, The Netherlands; Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. Department of Radiation Oncology, Eberhard-Karls-Universität Tübingen, Tübingen, Germany. Clinic for Particle Therapy, University Hospital Essen, West German Cancer Center (WTZ), Germany; West German Proton Therapy Center Essen (WPE), Germany; German Cancer Consortium (DKTK), partnersite Essen, Essen, Germany. Proton Therapy Center Czech, Prague, Czech Republic. Paul Scherrer Institut Center for Proton Therapy, ETH Domain, Villigen, Switzerland. The University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom; The Children's Brain Tumour Research Network, University of Manchester, Royal Manchester Children's Hospital, Manchester, United Kingdom. Danish Centre for Particle Therapy, Aarhus, Denmark; Norwegian Radiation and Nuclear Safety Authority, Oslo, Norway. Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Haaglanden Medisch Centrum, Department of Radiotherapy, Leidschendam, The Netherlands. Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; German Cancer Consortium (DKTK), partnersite Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumour Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association / Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany. KU Leuven - University of Leuven, Department of Oncology - Laboratory of Experimental Radiotherapy, Belgium; University Hospitals Leuven, Department of Radiation Oncology, Belgium; Particle Therapy Interuniversitary Center Leuven (PartICLe), Belgium; Leuven Kanker Instituut (LKI), UZ Leuven Gasthuisberg, Belgium.
    Issue Date
    2022
    
    Metadata
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    Abstract
    Purpose Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. Methods A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points. Results In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant the organ at risk threshold doses for recommended referral to specific organ specialists are defined. Conclusion These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. This will facilitate collaboration and further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.
    Citation
    De Roeck L, van der Weide HL, Eekers DBP, Kramer MC, Alapetite C, Blomstrand M, et al. The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation. Vol. 168, Radiotherapy and Oncology. Elsevier BV; 2022. p. 241–9. 
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/625062
    DOI
    10.1016/j.radonc.2022.01.018
    PubMed ID
    35093408
    Additional Links
    https://dx.doi.org/10.1016/j.radonc.2022.01.018
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.radonc.2022.01.018
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