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    LYMPHOMA: ADVANCES IN IMAGING AND RADIOTHERAPY SPECIAL FEATURE: COMMENTARY Progress and pitfalls with the use of image- guided personalised approaches in lymphoma

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    Authors
    Illidge, T. M.
    Phillips, E.
    Affiliation
    Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, NIHR Biomedical Research Centre, Manchester Academic Health Sciences Centre, Christie Hospital NHS Foundation Trust, Manchester, UK
    Issue Date
    2021
    
    Metadata
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    Abstract
    The use of 18F-FDG PET CT has become an essential part of the management of patients with lymphoma. The last decade has seen unrivalled progress in research efforts to personalise treatment approaches using PET as a predictive imaging biomarker. Critical to this success has been the standardisation of PET methods and reporting, including the 5-point Deauville scale, which has enabled the delivery of robust clinical trial data to develop response-adapted treatment approaches.(1, 2) The utility of PET as a predictive imaging biomarker in assessing treatment success or failure has been investigated extensively in malignant lymphomas. Considerable progress has been made over the last decade, in using PET to direct more personalised “risk-adapted” approaches, as well as an increased understanding of some of the limitations. Arguably the greatest success has been in Hodgkin Lymphoma (HL) where PET was initially demonstrated to be a powerful predictive biomarker (3) and is now routinely used in both early-stage and advanced HL to reduce or escalate the use of chemotherapy as well as guiding the delivery of more selective radiotherapy to patients.
    Citation
    Illidge TM, Phillips E. LYMPHOMA: ADVANCES IN IMAGING AND RADIOTHERAPY SPECIAL FEATURE: COMMENTARY Progress and pitfalls with the use of image- guided personalised approaches in lymphoma. British Journal of Radiology. 2021;94(1127):4.
    Journal
    British Journal of Radiology
    URI
    http://hdl.handle.net/10541/625043
    DOI
    10.1259/bjr.20210609
    Additional Links
    https://dx.doi.org/10.1259/bjr.20210609
    Type
    Other
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr.20210609
    Scopus Count
    Collections
    All Christie Publications

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