EVI1 protein interaction dynamics: targetable for therapeutic intervention?
Affiliation
Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKIssue Date
2021
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High expression of the transcriptional regulator EVI1 encoded at the MECOM locus at 3q26 is one of the most aggressive oncogenic drivers in acute myeloid leukemia (AML) and carries a very poor prognosis. How EVI1 confers leukemic transformation and chemotherapy resistance in AML is subject to important ongoing clinical and experimental studies. Recent discoveries have revealed critical details on genetic mechanisms of the activation of EVI1 overexpression and downstream events of aberrantly high EVI1 expression. Here we review and discuss aspects concerning the protein interactions of EVI1 and the related proteins MDS-EVI1 and ΔEVI1 from the perspective of their potential for therapeutic intervention.Citation
Paredes R, Doleschall N, Connors K, Geary B, Meyer S. EVI1 protein interaction dynamics: targetable for therapeutic intervention? Exp Hematol. 2021.Journal
Exp HematolDOI
10.1016/j.exphem.2021.12.398PubMed ID
34958895Additional Links
https://dx.doi.org/10.1016/j.exphem.2021.12.398Type
OtherLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.exphem.2021.12.398
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