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    Defining the Validity of Skin Self-Examination as a Screening Test for the Detection of Suspicious Pigmented Lesions: A Meta-Analysis of Diagnostic Test Accuracy

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    Authors
    Jiyad, Z.
    Plasmeijer, E. I.
    Keegan, S.
    Samarasinghe, V.
    Green, A. C.
    Akhras, V.
    Affiliation
    Department of Dermatology, St. George’s Hospital, London, United Kingdom
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Background: Skin self-examination (SSE) is widely promoted for the detection of suspicious pigmented lesions. However, determining screening accuracy is essential to appraising the usefulness of SSE. Objectives: The aim of this work was to pool estimates from studies of SSE diagnostic accuracy in the detection of suspicious pigmented lesions. Methods: This study was registered with PROSPERO (CRD42021246356) and conducted in accordance with PRISMA-DTA guidelines. A systematic search of Medline (PubMed) EMBASE, CINAHL, and The Cochrane Library was conducted to identify relevant studies. We included studies that examined the accuracy of SSE, either whole-body or site-specific, for detecting change in individual pigmented lesions or detecting an atypical naevus. A univariate random-effects model, based on logit-transformed data, was used to calculate a summary diagnostic odds ratio (DOR) as well as pooled sensitivity and specificity. Cochran’s Q test and the I2 statistic were calculated to assess heterogeneity. A proportional hazards model was used to calculate the area under the curve (AUC) and plot the summary receiver operator characteristic curve. We used the Quality Assessment of Diagnostic Accuracy Studies-2 tool to grade study quality. Results: We identified 757 studies, of which 3 met inclusion criteria for quantitative synthesis. The pooled sensitivity and specificity based on 553 included participants was 59 and 82%, respectively. The summary DOR was 5.88 and the AUC was 0.71. There were some concerns regarding risk of bias in all 3 studies. Conclusions: SSE can detect suspicious pigmented lesions with reasonable sensitivity and relatively high specificity, with the AUC suggesting acceptable discriminatory ability.
    Citation
    Jiyad Z, Plasmeijer EI, Keegan S, Samarasinghe V, Green AC, Akhras V. Defining the Validity of Skin Self-Examination as a Screening Test for the Detection of Suspicious Pigmented Lesions: A Meta-Analysis of Diagnostic Test Accuracy. Dermatology. 2022:1-9.
    Journal
    Dermatology
    URI
    http://hdl.handle.net/10541/625032
    DOI
    10.1159/000520592
    PubMed ID
    34979506
    Additional Links
    https://dx.doi.org/10.1159/000520592
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1159/000520592
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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