Affiliation
Department of Medical Oncology, Rhodes General Hospital, 85100 Rhodes, GreeceIssue Date
2021
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Show full item recordAbstract
Hippo pathway with its main molecule YAP is a crucial pathway for development, tissue homeostasis, wound healing, tissue regeneration, and cancer. In this review, we discuss the multiple effects of the YAP/Hippo pathway in the immune system and cancer. We analyzed a series of effects: extracellular vesicles enhanced immunity through inhibition of LATS1/2, ways of modulation of the tumor microenvironment, YAP- and TAZ-mediated upregulation of PDL1, high expression of YAP and PDL1 in EGFR-TKI-resistant cells, enhanced YAP activity in inflammation, and the effect of the Hippo pathway on T cells, B cells, Tregs, macrophages, and myeloid-derived suppressor cells (MDSCs). These pleiotropic effects render the YAP and Hippo pathway a key pathway for exploitation in the future, in order to enhance our immunotherapy treatment strategies in oncology.Citation
Matthaios D, Tolia M, Mauri D, Kamposioras K, Karamouzis M. YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango. Biomedicines. 2021;9(12):13.Journal
BiomedicinesDOI
10.3390/biomedicines9121949PubMed ID
34944765Additional Links
https://dx.doi.org/10.3390/biomedicines9121949Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3390/biomedicines9121949
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