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    YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango

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    Authors
    Matthaios, D.
    Tolia, M.
    Mauri, D.
    Kamposioras, K.
    Karamouzis, M.
    Affiliation
    Department of Medical Oncology, Rhodes General Hospital, 85100 Rhodes, Greece
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Hippo pathway with its main molecule YAP is a crucial pathway for development, tissue homeostasis, wound healing, tissue regeneration, and cancer. In this review, we discuss the multiple effects of the YAP/Hippo pathway in the immune system and cancer. We analyzed a series of effects: extracellular vesicles enhanced immunity through inhibition of LATS1/2, ways of modulation of the tumor microenvironment, YAP- and TAZ-mediated upregulation of PDL1, high expression of YAP and PDL1 in EGFR-TKI-resistant cells, enhanced YAP activity in inflammation, and the effect of the Hippo pathway on T cells, B cells, Tregs, macrophages, and myeloid-derived suppressor cells (MDSCs). These pleiotropic effects render the YAP and Hippo pathway a key pathway for exploitation in the future, in order to enhance our immunotherapy treatment strategies in oncology.
    Citation
    Matthaios D, Tolia M, Mauri D, Kamposioras K, Karamouzis M. YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango. Biomedicines. 2021;9(12):13.
    Journal
    Biomedicines
    URI
    http://hdl.handle.net/10541/625031
    DOI
    10.3390/biomedicines9121949
    PubMed ID
    34944765
    Additional Links
    https://dx.doi.org/10.3390/biomedicines9121949
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/biomedicines9121949
    Scopus Count
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