• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    34789728.pdf
    Size:
    2.141Mb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Schenk, Maximilian W.
    Humphrey, Sam
    Hossain, AS Md Mukarram
    Revill, Mitchell
    Pearsall, Sarah
    Lallo, Alice
    Brown, Stewart
    Bratt, Samuel
    Galvin, Melanie
    Descamps, Tine
    Zhou, Cong
    Pearce, Simon P
    Priest, Lynsey
    Greenhalgh, Michelle
    Chaturvedi, Anshuman
    Kerr, Alastair
    Blackhall, Fiona H
    Dive, Caroline
    Frese, Kristopher K.
    Show allShow less
    Affiliation
    Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester, Alderley Park, Macclesfield, SK10 4TG,
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Small cell lung cancer (SCLC) has a 5-year survival rate of <7%. Rapid emergence of acquired resistance to standard platinum-etoposide chemotherapy is common and improved therapies are required for this recalcitrant tumour. We exploit six paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models from donors with extensive stage SCLC to investigate changes at disease progression after chemotherapy. Soluble guanylate cyclase (sGC) is recurrently upregulated in post-chemotherapy progression CDX models, which correlates with acquired chemoresistance. Expression and activation of sGC is regulated by Notch and nitric oxide (NO) signalling with downstream activation of protein kinase G. Genetic targeting of sGC or pharmacological inhibition of NO synthase re-sensitizes a chemoresistant CDX progression model in vivo, revealing this pathway as a mediator of chemoresistance and potential vulnerability of relapsed SCLC.
    Citation
    Schenk MW, Humphrey S, Hossain ASMM, Revill M, Pearsall S, Lallo A, et al. Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer Vol. 12, Nature Communications. Springer Science and Business Media LLC; 2021.
    Journal
    Nature Communications
    URI
    http://hdl.handle.net/10541/624936
    DOI
    10.1038/s41467-021-26823-6
    PubMed ID
    34789728
    Type
    Article
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-021-26823-6
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.
    • Authors: Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D
    • Issue date: 2019 Feb 5
    • Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells.
    • Authors: El-Sehemy A, Chang AC, Azad AK, Gupta N, Xu Z, Steed H, Karsan A, Fu Y
    • Issue date: 2013 Dec
    • [Establishment of A Patient-derived Xenotransplantation Animal Model for Small Cell Lung Cancer and Drug Resistance Model].
    • Authors: Zhu Y, Huang W, Wu Y, Jia L, Li Y, Chen R, Guo L, Chen Q
    • Issue date: 2019 Jan 20
    • Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.
    • Authors: Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J
    • Issue date: 2017 May 18
    • A novel mutation panel for predicting etoposide resistance in small-cell lung cancer.
    • Authors: Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J
    • Issue date: 2019
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.