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dc.contributor.authorDuane, F.
dc.contributor.authorKerr, A.
dc.contributor.authorAznar, Marianne Camille
dc.contributor.authorWang, Z.
dc.contributor.authorNtentas, G.
dc.contributor.authorDarby, S.
dc.contributor.authorTaylor, C.
dc.date.accessioned2022-01-11T11:59:59Z
dc.date.available2022-01-11T11:59:59Z
dc.date.issued2021en
dc.identifier.citationDuane F, Kerr A, Aznar M, Wang Z, Ntentas G, Darby S, et al. Oesophagus exposure in breast cancer radiotherapy: systematic review of oesophageal doses 2010-2020. Radiotherapy and Oncology. 2021;161:S937-S.en
dc.identifier.urihttp://hdl.handle.net/10541/624930
dc.description.abstractPurpose or Objective Breast cancer radiotherapy has been shown to increase the risk of subsequent primary oesophageal cancer. It is unclear if avoidance of the oesophagus is being considered routinely during radiotherapy treatment planning. This study aims to describe exposure of the oesophagus from modern breast cancer regimens. Materials and Methods A systematic review of oesophageal doses from breast cancer radiotherapy regimens published 2010-2020 was undertaken. Average mean oesophageal doses and average maximum oesophageal doses were described for different anatomical regions irradiated and techniques used. Oesophageal exposure from current modern regimens was compared to that received in previous decades. Results 112 regimens from 18 countries reporting oesophagus doses were identified. The average mean oesophagus dose was 0.2 Gy (range 0.1-0.4) for partial breast irradiation, 2.7 Gy (range 0.1-16.6) for whole breast/chest wall radiotherapy and 11.4 Gy (range 0.0–31.9) with the addition of regional nodal irradiation. For regimens that included regional nodal irradiation, the average mean oesophageal dose was higher for IMRT (17.5 Gy static IMRT, 12.5 Gy rotational IMRT) than tangential radiotherapy (7.5 Gy) (p < 0.001). Overall, average oesophageal exposure from modern regimens was similar to that estimated from regimens used in previous decades. Conclusion Exposure of the oesophagus remains an issue in modern breast cancer radiotherapy particularly for patients undergoing IMRT. Routine avoidance of the oesophagus during treatment planning may reduce the number of women developing a subsequent primary oesophageal cancer in the future.en
dc.titleOesophagus exposure in breast cancer radiotherapy: systematic review of oesophageal doses 2010-2020en
dc.typeMeetings and Proceedingsen
dc.contributor.departmentRadiation Oncology, St Luke's Radiation Oncology Network, Dublin, Ireland;en
dc.identifier.journalRadiotherapy and Oncologyen
dc.description.noteen]


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