• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Acute toxicity of hypo- and conventionally-fractionated radiosensitised bladder radiotherapy

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Huddart, R.
    Hafeez, S.
    Omar, A.
    Choudhury, Ananya
    Birtle, A.
    Syndikus, I.
    Hindson, B.
    Varughese, M.
    Henry, A.
    McLaren, D.
    Foroud, F.
    Webster, A.
    McNair, H.
    Tolentino, A.
    Webster, L.
    Gribble, H.
    Philipps, L.
    Nikapota, A.
    Parikh, O.
    Alonzi, R.
    Mahmood, R.
    Hilman, S.
    Rimmer, Y.
    Griffin, C.
    Hall, E.
    Show allShow less
    Affiliation
    Institute of Cancer Research , Clinical Academic Radiotherapy, London, United Kingdom
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Purpose or Objective Adding concurrent (chemo-)therapy to radiotherapy improves outcomes for muscle invasive bladder cancer patients. Recent meta-analysis demonstrates superior invasive locoregional disease control for a hypofractionated 55 gray (Gy) in 20 fractions (f) schedule compared to 64Gy in 32f. In the RAIDER clinical trial, patients undergoing 20f or 32f radical radiotherapy were randomised (1:1:2) to standard radiotherapy or to standard-dose or escalated-dose adaptive radiotherapy. Neoadjuvant chemotherapy and concomitant therapy were permitted in line with standard practice at each participant’s centre. We report acute toxicity by concomitant therapy-fractionation schedule combination. Materials and Methods Trial participants had unifocal bladder TCC staged T2-T4a N0 M0. Acute toxicity was assessed (CTCAE) weekly during radiotherapy and at 10 weeks after start of treatment. Within each fractionation cohort, a non-randomised comparison of the proportion of patients reporting grade 2 or worse (G2+) genitourinary (GU), gastrointestinal (GI) or other adverse events at any point in the acute period was performed using Fisher’s exact tests. Results Between October 2015 and April 2020, 345 (163 20f; 182 32f) patients were recruited from 46 centres. Median age was 73 years; 49% received neoadjuvant chemotherapy. 332 patients received study treatment of whom 244 (73%) received concomitant therapy (table 1). In those having concomitant therapy, acute G2+ toxicity was reported by 88/114 (77%) in 20f cohort and 102/130 (78%) in 32f cohort and is reported for the 3 most common regimens in table 2. The proportion of patients with G2+ GI toxicity differed by regimen (20f p=0.01; 32f p=0.005). The most common GI toxicities were diarrhoea (20f: 15.9%, 45.0%. 11.1%; 32f: 10.6%, 22.7%, 27.2% for the MMC/5FU, gemcitabine (G) and carbogen/nicotinamide (BCON) groups respectively) and anorexia (20f: 11.4%, 12.5%, 18.5%; 32f: 6.4%, 18.2%, 18.2% for MC/5FU, G, BCON respectively). G2+ acute adverse events are common with overall rates similar across concomitant therapy-fractionation schedules. The toxicity profile varied by type of concurrent treatment; for both fractionation schedules, GI toxicity rate appear higher in patients receiving gemcitabine.
    Citation
    Huddart R, Hafeez S, Omar A, Choudhury A, Birtle A, Syndikus I, et al. Acute toxicity of hypo- and conventionally-fractionated radiosensitised bladder radiotherapy. Radiotherapy and Oncology. 2021;161:S396-S8.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/624839
    Type
    Meetings and Proceedings
    Language
    en
    Collections
    All Christie Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.