• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    NLR & ALC as prognostic markers in patients treated with curative intent radiotherapy for NSCLC

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Hiley, C.
    Punjabi, A.
    Barrett, E.
    Cheng, A.
    Mulla, A.
    Walls, G.
    Johnston, D.
    McAleese, J.
    Moore, K.
    Hicks, J.
    Blyth, K.
    Denholm, M.
    Magee, L.
    Gilligan, D.
    Silverman, S.
    Qureshi, M.
    Clinch, H.
    Hatton, M.
    Philips, L.
    Brown, S.
    O'Brien, M.
    Macdonald, F.
    Faivre-Finn, Corinne
    Evison, M.
    Show allShow less
    Affiliation
    University College London, CRUK Lung Cancer Centre of Excellence, London
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Purpose or Objective Neutrophil-Lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) have been proposed as prognostic markers in non-small cell lung cancer (NSCLC). The objective of this study was to examine the association of NLR/ALC pre and post curative-intent radiotherapy (RT) for NSCLC on disease recurrence and overall survival. Materials and Methods A retrospective study of consecutive patients who underwent curative-intent RT for NSCLC across 9 sites in the UK from 01/10/2014 to 01/10/2016. A multivariate analysis was performed to assess the ability of pre-treatment NLR/ALC, post-treatment NLR/ALC and change in NLR/ALC, adjusted for co-founding factors using the Cox proportional hazards model, to predict disease recurrence and overall survival (OS) within 2 years of treatment. Results 425 patients were identified with complete blood parameter values. Higher pre-NLR, post-NLR and change in NLR plus lower post ALC were all independent predictors of worse survival. Receiver operator curve analysis found a pre-NLR >2.5 (OR 1.71, 95%CI 1.06-2.79, p< 0.05), a post-NLR >5.5 (OR 2.36, 95%CI 1.49-3.76, p< 0.001], a change in NLR >3.6 (OR 2.41, 95%CI 1.5-3.91, p<0.001) and a post-ALC <0.8 (OR 2.86, 95%CI 1.76- 4.69, p <0.001) optimally predicted poor overall survival on both univariate and multivariate analysis when adjusted for cofounding factors. None of the NLR/ALC parameters were independent predictors of disease recurrence. Conclusion NLR and ALC, surrogate markers for systemic inflammation, have prognostic value in NSCLC patients treated with curative intent radiotherapy. These simple and readily available parameters may have a future role in risk stratification post treatment to inform the intensity of surveillance protocols.
    Citation
    Hiley C, Punjabi A, Barrett E, Cheng A, Mulla A, Walls G, et al. NLR & ALC as prognostic markers in patients treated with curative intent radiotherapy for NSCLC. Radiotherapy and Oncology. 2021;161:S183-S4.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/624833
    Type
    Meetings and Proceedings
    Language
    en
    Collections
    All Christie Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.