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dc.contributor.authorElumalai, Thiraviyam
dc.contributor.authorSong, Yee Pei
dc.contributor.authorMistry, Hitesh
dc.contributor.authorDubec, Michael
dc.contributor.authorJackson, S.
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorHoskin, Peter J
dc.contributor.authorChoudhury, Ananya
dc.contributor.authorMcWilliam, Alan
dc.date.accessioned2022-01-11T11:59:37Z
dc.date.available2022-01-11T11:59:37Z
dc.date.issued2021en
dc.identifier.citationElumalai T, Song YP, Mistry H, Dubec M, Jackson S, Herk MV, et al. Impact of inter-observer variability on MRI radiomic features in bladder cancer. Radiotherapy and Oncology. 2021;161:S1524-S5.en
dc.identifier.urihttp://hdl.handle.net/10541/624828
dc.description.abstractPurpose or Objective Muscle-invasive bladder cancer (MIBC) can be radically treated with either surgery or radiotherapy. Regardless of treatment, overall 5-year survival remains poor with 1 in 2 patients dying of disease. Improved patient stratification is needed, identifying those who respond better to radiotherapy. Using imaging biomarkers from on-treatment MRI such as radiomic features is one viable strategy. We aimed to identify MRI radiomic features robust for inter-observer variation in MIBC patients treated with chemo-radiotherapy and compare bladder wall (BW) and tumour bed (TB). Materials and Methods Ten eligible MIBC patients were recruited to an MRI imaging study while undergoing chemo-radiotherapy. All patients were treated with GemX (52.5 /20 fractions with Gemcitabine 100 mg/m2 weekly). Weekly scans were taken during treatment on a Siemens 1.5T diagnostic MRI scanner. BW and TB were segmented as the region of interests on the weekly T2-weighted MRI images by two clinical oncologists to evaluate inter-observer variability. In total, 40 MRI images were available to extract features using pyRadiomics (v3.0.1). Robustness to inter-observer variation was assessed using the intraclass correlation coefficient (ICC). Distribution of features in BW and TB was compared using inter-quartile range.en
dc.language.isoenen
dc.titleImpact of inter-observer variability on MRI radiomic features in bladder canceren
dc.typeMeetings and Proceedingsen
dc.contributor.departmentThe Christie NHS foundation trust, Clinical Oncology, Manchesteren
dc.identifier.journalRadiotherapy and Oncologyen
dc.description.noteen]


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