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dc.contributor.authorDatta, Anubhav
dc.contributor.authorForker, Laura-Jane
dc.contributor.authorMcWilliam, Alan
dc.contributor.authorMistry, Hitesh
dc.contributor.authorZhong, J.
dc.contributor.authorWylie, James P
dc.contributor.authorCoyle, Catherine
dc.contributor.authorSaunders, Daniel
dc.contributor.authorKennedy, S.
dc.contributor.authorO'Connor, James P B
dc.contributor.authorHoskin, Peter J
dc.contributor.authorWest, Catherine M L
dc.contributor.authorChoudhury, Ananya
dc.date.accessioned2022-01-11T11:59:32Z
dc.date.available2022-01-11T11:59:32Z
dc.date.issued2021en
dc.identifier.citationDatta A, Forker L, McWilliam A, Mistry H, Zhong J, Wylie J, et al. Association of radiomic features with aggressive phenotypes in soft tissue sarcomas. Radiotherapy and Oncology. 2021;161:S1162-S3.en
dc.identifier.urihttp://hdl.handle.net/10541/624809
dc.description.abstractPurpose or Objective Soft tissue sarcomas(STS) are rare and heterogeneous tumours with variable outcomes. Improving survival requires identifying and targeting aggressive phenotypes. Novel ways of stratifying patients include a clinical prognostic nomogram(Sarculator; includes tumour size) and a gene expression derived hypoxia score(HS). We investigate the feasibility of non-invasive and repeatable imaging to assess clinically/biologically relevant and targetable phenotypes. Materials and Methods Retrospective analysis of 43 extremity STS patients with matched diagnostic biopsy-imaging data was performed. Imaging was acquired at several different hospitals in the region using various scanners/protocols. Patients underwent curative-intent surgery±adjuvant radiotherapy. HS(24-gene signature) were measured using NanoString. Sarculator predicted 10yr OS. Treatment naïve T1(n=41) and T2(n=28) weighted sequences were segmented by two radiologists using Raystation. Histogram normalisation and gray-level intensity discretisation steps were performed. PyRadiomics v3.0.1 was used to extract features and robustness was assessed using intra-class correlation(ICC; threshold >0.9). Features with a high degree of association within their classes were further selected using Spearman’s rank correlation. Associations with Sarculator and HS were determined using rank correlation matrices and principal component analysis(PCA). Significance levels were set at p<0.05. Results ICC identified 63(T1) and 68(T2) features. Further selection resulted in 4(T1) and 14(T2) exploratory features. Sarculator correlated strongly with T1(ρ=-0.75) and T2(ρ=-0.84) volume features (Fig 1). T1 size(ρ=0.44) correlated strongest with HS. Top T2 features, gray-level non-uniformity(GLN) and zone entropy(ZE), correlated with Sarculator(ρ=-0.57,ρ=-0.56 respectively) and with hypoxia(ρ=-0.37,ρ=0.39 respectively). GLN is a gray-level run length matrix (GLRLM) feature quantifying variability of gray-level intensity. ZE is a gray-level size zone matrix feature quantifying randomness in distribution zone sizes and gray levels. High GLN values indicate more heterogeneity in intensity; high ZE values indicate more heterogeneity in texture. PCA identified clusters using the patient radiomics values, and box plots highlight differences (Fig 2). T1 derived features were significantly different between the 3 groups for Sarculator(p=0.013) but not HS(p=0.156). There were no significant differences identified by T2 derived features for Sarculator(p=0.088) or HS(p=0.676). Conclusion Shape-related T1- and T2- MRI derived radiomics features of STS correlated with Sarculator but less well with HS. The T1 radiomic values differentiated patient groups with different Sarculator scores, suggesting potential to non-invasively identify aggressive STS phenotypes. Radiomic profiling of STS is feasible and further study is worthwhile.en
dc.language.isoenen
dc.titleAssociation of radiomic features with aggressive phenotypes in soft tissue sarcomasen
dc.typeMeetings and Proceedingsen
dc.contributor.departmentUniversity of Manchester, Division of Cancer Sciences, Manchesteren
dc.identifier.journalRadiotherapy and Oncologyen
dc.description.noteen]


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