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    BH3-mimetics: recent developments in cancer therapy

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    Authors
    Townsend, Paul A
    Kozhevnikova, M. V.
    Cexus, O. N. F.
    Zamyatnin, A. A., Jr.
    Soond, S. M.
    Affiliation
    University of Surrey, Guildford, UK.
    Issue Date
    2021
    
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    Abstract
    The hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis pathway in a variety of diseased states. Not only have such rational approaches in drug design yielded several key therapeutics, such outputs have also offered insights into the integrated mechanistic aspects of basic and clinical research at the genetics level for the future. In no other area of medical research have the effects of such work been felt, than in cancer research, through targeting the BAX-Bcl-2 protein-protein interactions. With these promising outputs in mind, several mimetics, and their potential therapeutic applications, have also been developed for several other pathological conditions, such as cardiovascular disease and tissue fibrosis, thus highlighting the universal importance of the intrinsic arm of the apoptosis pathway and its input to general tissue homeostasis. Considering such recent developments, and in a field that has generated so much scientific interest, we take stock of how the broadening area of BH3-mimetics has developed and diversified, with a focus on their uses in single and combined cancer treatment regimens and recently explored therapeutic delivery methods that may aid the development of future therapeutics of this nature.
    Citation
    Townsend PA, Kozhevnikova MV, Cexus ONF, Zamyatnin AA Jr, Soond SM. BH3-mimetics: recent developments in cancer therapy [Internet]. Vol. 40, Journal of Experimental & Clinical Cancer Research. Springer Science and Business Media LLC; 2021.
    Journal
    Journal of Experimental and Clinical Cancer Research
    URI
    http://hdl.handle.net/10541/624803
    DOI
    10.1186/s13046-021-02157-5
    PubMed ID
    34753495
    Additional Links
    https://dx.doi.org/10.1186/s13046-021-02157-5
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13046-021-02157-5
    Scopus Count
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    All Paterson Institute for Cancer Research

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