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    The role of circular RNAs in DNA damage response and repair

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    Authors
    Papaspyropoulos, A.
    Hazapis, O.
    Lagopati, N.
    Polyzou, A.
    Papanastasiou, A. D.
    Liontos, M.
    Gorgoulis, Vassilis G
    Kotsinas, A.
    Affiliation
    Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
    Issue Date
    2021
    
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    Abstract
    Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs that are abundantly expressed in the cell. CircRNAs have the capacity to regulate gene expression by interacting with regulatory proteins and/or other classes of RNAs. While a vast number of circRNAs have been discovered, the majority still remains poorly characterized. Particularly, there is no detailed information on the identity and functional role of circRNAs that are transcribed from genes encoding components of the DNA damage response and repair (DDRR) network. In this article, we not only review the available published information on DDRR-related circRNAs, but also conduct a bioinformatic analysis on data obtained from public repositories to uncover deposited, yet uncharacterized circRNAs derived from components of the DDRR network. Finally, we interrogate for potential targets that are regulated by this class of molecules and look into potential functional implications.
    Citation
    Papaspyropoulos A, Hazapis O, Lagopati N, Polyzou A, Papanastasiou AD, Liontos M, et al. The Role of Circular RNAs in DNA Damage Response and Repair [Internet]. Vol. 13, Cancers. MDPI AG; 2021. p. 5352.
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/624801
    DOI
    10.3390/cancers13215352
    PubMed ID
    34771517
    Additional Links
    https://dx.doi.org/10.3390/cancers13215352
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers13215352
    Scopus Count
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    All Paterson Institute for Cancer Research

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