Mutational characterization of cutaneous melanoma supports divergent pathways model for melanoma development
Authors
Millán-Esteban, D.Peña-Chilet, M.
García-Casado, Z.
Manrique-Silva, E.
Requena, C.
Bañuls, J.
López-Guerrero, J. A.
Rodríguez-Hernández, A.
Traves, V.
Dopazo, J.
Virós, Amaya
Kumar, R.
Nagore, E.
Affiliation
School of Medicine, Universidad Católica de València San Vicente Mártir, 46001 Valencia, SpainIssue Date
2021
Metadata
Show full item recordAbstract
According to the divergent pathway model, cutaneous melanoma comprises a nevogenic group with a propensity to melanocyte proliferation and another one associated with cumulative solar damage (CSD). While characterized clinically and epidemiologically, the differences in the molecular profiles between the groups have remained primarily uninvestigated. This study has used a custom gene panel and bioinformatics tools to investigate the potential molecular differences in a thoroughly characterized cohort of 119 melanoma patients belonging to nevogenic and CSD groups. We found that the nevogenic melanomas had a restricted set of mutations, with the prominently mutated gene being BRAF. The CSD melanomas, in contrast, showed mutations in a diverse group of genes that included NF1, ROS1, GNA11, and RAC1. We thus provide evidence that nevogenic and CSD melanomas constitute different biological entities and highlight the need to explore new targeted therapies.Citation
Millán-Esteban D, Peña-Chilet M, García-Casado Z, Manrique-Silva E, Requena C, Bañuls J, et al. Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development [Internet]. Vol. 13, Cancers. MDPI AG; 2021. p. 5219.Journal
CancersDOI
10.3390/cancers13205219PubMed ID
34680367Additional Links
https://dx.doi.org/10.3390/cancers13205219Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3390/cancers13205219
Scopus Count
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