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    Mutational characterization of cutaneous melanoma supports divergent pathways model for melanoma development

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    Authors
    Millán-Esteban, D.
    Peña-Chilet, M.
    García-Casado, Z.
    Manrique-Silva, E.
    Requena, C.
    Bañuls, J.
    López-Guerrero, J. A.
    Rodríguez-Hernández, A.
    Traves, V.
    Dopazo, J.
    Virós, Amaya
    Kumar, R.
    Nagore, E.
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    Affiliation
    School of Medicine, Universidad Católica de València San Vicente Mártir, 46001 Valencia, Spain
    Issue Date
    2021
    
    Metadata
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    Abstract
    According to the divergent pathway model, cutaneous melanoma comprises a nevogenic group with a propensity to melanocyte proliferation and another one associated with cumulative solar damage (CSD). While characterized clinically and epidemiologically, the differences in the molecular profiles between the groups have remained primarily uninvestigated. This study has used a custom gene panel and bioinformatics tools to investigate the potential molecular differences in a thoroughly characterized cohort of 119 melanoma patients belonging to nevogenic and CSD groups. We found that the nevogenic melanomas had a restricted set of mutations, with the prominently mutated gene being BRAF. The CSD melanomas, in contrast, showed mutations in a diverse group of genes that included NF1, ROS1, GNA11, and RAC1. We thus provide evidence that nevogenic and CSD melanomas constitute different biological entities and highlight the need to explore new targeted therapies.
    Citation
    Millán-Esteban D, Peña-Chilet M, García-Casado Z, Manrique-Silva E, Requena C, Bañuls J, et al. Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development [Internet]. Vol. 13, Cancers. MDPI AG; 2021. p. 5219.
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/624795
    DOI
    10.3390/cancers13205219
    PubMed ID
    34680367
    Additional Links
    https://dx.doi.org/10.3390/cancers13205219
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers13205219
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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