• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Experimental challenges to modeling prostate cancer heterogeneity

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Flores-Téllez, Teresita
    Baena, Esther
    Affiliation
    Prostate Oncobiology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, Macclesfield, SK10 4TG
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Tumor heterogeneity plays a key role in prostate cancer prognosis, therapy selection, relapse, and acquisition of treatment resistance. Prostate cancer presents a heterogeneous diversity at inter- and intra-tumor and inter-patient levels which are influenced by multiple intrinsic and/or extrinsic factors. Recent studies have started to characterize the complexity of prostate tumors and these different tiers of heterogeneity. In this review, we discuss the most common factors that contribute to tumoral diversity. Moreover, we focus on the description of the in vitro and in vivo approaches, as well as high-throughput technologies, that help to model intra-tumoral diversity. Further understanding tumor heterogeneities and the challenges they present will guide enhanced patient risk stratification, aid the design of more precise therapies, and ultimately help beat this chameleon-like disease.
    Citation
    Flores-Téllez T del NJ, Baena E. Experimental challenges to modeling prostate cancer heterogeneity [Internet]. Vol. 524, Cancer Letters. Elsevier BV; 2022. p. 194–205.
    Journal
    Cancer Letters
    URI
    http://hdl.handle.net/10541/624794
    DOI
    10.1016/j.canlet.2021.10.012
    PubMed ID
    34688843
    Additional Links
    https://dx.doi.org/10.1016/j.canlet.2021.10.012
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.canlet.2021.10.012
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Nanoways to overcome docetaxel resistance in prostate cancer.
    • Authors: Ganju A, Yallapu MM, Khan S, Behrman SW, Chauhan SC, Jaggi M
    • Issue date: 2014 Apr
    • Genomic and phenotypic heterogeneity in prostate cancer.
    • Authors: Haffner MC, Zwart W, Roudier MP, True LD, Nelson WG, Epstein JI, De Marzo AM, Nelson PS, Yegnasubramanian S
    • Issue date: 2021 Feb
    • Spatial Intratumor Genomic Heterogeneity within Localized Prostate Cancer Revealed by Single-nucleus Sequencing.
    • Authors: Su F, Zhang W, Zhang D, Zhang Y, Pang C, Huang Y, Wang M, Cui L, He L, Zhang J, Zou L, Zhang J, Li W, Li L, Shao J, Ma J, Xiao F, Liu M
    • Issue date: 2018 Nov
    • Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance.
    • Authors: Marusyk A, Janiszewska M, Polyak K
    • Issue date: 2020 Apr 13
    • Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence.
    • Authors: Nickel GC, Barnholtz-Sloan J, Gould MP, McMahon S, Cohen A, Adams MD, Guda K, Cohen M, Sloan AE, LaFramboise T
    • Issue date: 2012
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.