Sociodemographic and geographical variation in access to systemic anti-cancer therapies for women with advanced breast cancer: a systematic review
dc.contributor.author | Pearson, Sally Anne | |
dc.contributor.author | Taylor, Sally | |
dc.contributor.author | Marsden, A. | |
dc.contributor.author | O'Reilly, J. D. | |
dc.contributor.author | Howell, Sacha J | |
dc.contributor.author | Yorke, Janelle | |
dc.date.accessioned | 2021-11-26T10:04:44Z | |
dc.date.available | 2021-11-26T10:04:44Z | |
dc.date.issued | 2021 | en |
dc.identifier.citation | Pearson SA, Taylor S, Marsden A, O'Reilly JD, Howell S, Yorke J. Sociodemographic and geographical variation in access to systemic anti-cancer therapies for women with advanced breast cancer: a systematic review. Breast. 2021;59:S40-S1. | en |
dc.identifier.uri | http://hdl.handle.net/10541/624788 | |
dc.description.abstract | Background: Equitable access to guideline concordant treatment with systemic anti-cancer therapies (SACT) is a key determinant in overall survival, progression free survival and improvement in quality of life for Advanced Breast Cancer (ABC). Variation in treatment receipt has been reported though remains poorly understood. A comprehensive understanding of factors which influence access and receipt of guideline concordant treatment is lacking. The review sought to address this through identifying and investigating factors associated with access to and receipt of guideline concordant SACT for women with ABC. Methods: Systematic searches of the literature were undertaken using EBSCO CINAHL Plus, Ovid MEDLINE, Ovid EMBASE, PsychINFO, Cochrane Library, JBI database and NHS Evidence. Methodological quality was assessed by two reviewers using the Joanna Briggs Institute critical appraisal tool (JBI, 2017) with the application of an overall GRADE quality rating. Studies were synthesised using a narrative synthesis approach. High levels of heterogeneity between studies precluded meta-analysis. Results: Thirteen international studies (n=13) published between 2009 and 2020 were included and reported 201,677 patients with ABC. Overall receipt of SACT ranged from 4% to 70%, factors associated with receipt were: • Age: younger patients had an increased likelihood of treatment receipt in a timelier manner • Race/ethnicity: patients of white origin were more likely to receive treatment in a timelier manner than patients of non-white origin. • Socioeconomic status: patients with higher socioeconomic status were more likely to receive treatment than their counterparts • Comorbidities: patients with fewer comorbidities were more likely to receive treatment • Place of care: patients treated at teaching, research and private institutions were more likely to receive timelier treatment • Geographical location: treatment receipt varied by geographical location Conclusion: A number of factors were associated with treatment receipt. Barriers included older age, non-white race, lower socioeconomic status, significant comorbidities, hospital setting and geographical location. However, due to limitations in overall methodological quality findings should be interpreted with caution. Implications for nursing, practice and research include the development and piloting of targeted interventions to address specific barriers in a socio-culturally sensitive manner and further research to understand the experience of women and clinicians is required. | en |
dc.language.iso | en | en |
dc.title | Sociodemographic and geographical variation in access to systemic anti-cancer therapies for women with advanced breast cancer: a systematic review | en |
dc.type | Other | en |
dc.contributor.department | University of Manchester, England; | en |
dc.identifier.journal | Breast | en |
dc.description.note | en] |