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dc.contributor.authorAli, Amin
dc.contributor.authorDu Feu, Alexander
dc.contributor.authorOliveira, Pedro
dc.contributor.authorChoudhury, Ananya
dc.contributor.authorBristow, Robert G
dc.contributor.authorBaena, Esther
dc.date.accessioned2021-11-26T10:04:35Z
dc.date.available2021-11-26T10:04:35Z
dc.date.issued2021en
dc.identifier.citationAli A, Du Feu A, Oliveira P, Choudhury A, Bristow RG, Baena E. Prostate zones and cancer: lost in transition? [Internet]. Nature Reviews Urology. Springer Science and Business Media LLC; 2021.en
dc.identifier.pmid34667303en
dc.identifier.doi10.1038/s41585-021-00524-7en
dc.identifier.urihttp://hdl.handle.net/10541/624755
dc.description.abstractLocalized prostate cancer shows great clinical, genetic and environmental heterogeneity; however, prostate cancer treatment is currently guided solely by clinical staging, serum PSA levels and histology. Increasingly, the roles of differential genomics, multifocality and spatial distribution in tumorigenesis are being considered to further personalize treatment. The human prostate is divided into three zones based on its histological features: the peripheral zone (PZ), the transition zone (TZ) and the central zone (CZ). Each zone has variable prostate cancer incidence, prognosis and outcomes, with TZ prostate tumours having better clinical outcomes than PZ and CZ tumours. Molecular and cell biological studies can improve understanding of the unique molecular, genomic and zonal cell type features that underlie the differences in tumour progression and aggression between the zones. The unique biology of each zonal tumour type could help to guide individualized treatment and patient risk stratification.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41585-021-00524-7en
dc.titleProstate zones and cancer: lost in transition?en
dc.typeOtheren
dc.contributor.departmentProstate Oncobiology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchesteren
dc.identifier.journalNature Reviews Urologyen
dc.description.noteen]


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