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    Reorganization of the 3D genome pinpoints non-coding drivers of primary prostate tumors

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    Authors
    Hawley, J. R.
    Zhou, S.
    Arlidge, C.
    Grillo, G.
    Kron, K. J.
    Hugh-White, R.
    van der Kwast, T. H.
    Fraser, M.
    Boutros, P. C.
    Bristow, Robert G
    Lupien, M.
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    Affiliation
    Medical Biophysics, University of Toronto, Princess Margaret Cancer Center-University Health Network, Ontario Institute for Cancer Research
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Prostate cancer is a heterogeneous disease whose progression is linked to genome instability. However, the impact of this instability on the non-coding genome and its three-dimensional organization to aid progression is unclear. Using primary benign and tumor tissue, we find a high concordance in higher order three-dimensional genome organization. This concordance argues for constraints to the topology of prostate tumor genomes. theless, we identified changes in focal chromatin interactions, typical of loops bridging non-coding cis-regulatory elements, and showed how structural variants can induce these changes to guide cis-regulatory element hijacking. Such events resulted in opposing differential expression of genes found at antipodes of rearrangements. Collectively, these results argue that changes to focal chromatin interactions, as opposed to higher order genome organization, allow for aberrant gene regulation and are repeatedly mediated by structural variants in primary prostate cancer.
    Citation
    Hawley JR, Zhou S, Arlidge C, Grillo G, Kron KJ, Hugh-White R, et al. Reorganization of the 3D genome pinpoints non-coding drivers of primary prostate tumors. Cancer Research. American Association for Cancer Research (AACR); 2021. p. canres.CAN-21-2056-E.2021.
    Journal
    Cancer Research
    URI
    http://hdl.handle.net/10541/624744
    DOI
    10.1158/0008-5472.Can-21-2056
    PubMed ID
    34642184
    Additional Links
    https://dx.doi.org/10.1158/0008-5472.Can-21-2056
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1158/0008-5472.Can-21-2056
    Scopus Count
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    All Paterson Institute for Cancer Research

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