COVID-19 and cancer: First report of the ESMO international, registry-based, cohort study (ESMO CoCARE)
Authors
Romano, E.Gennatas, S.
Rogado, J.
Sekacheva, M.
Vinal, D.
Lee, Rebecca J
Croitoru, A. E.
Vitorino, M.
Khallaf, S. M.
Susnjar, S.
Widyanti, S.
Cardena, A.
Djerouni, M.
Rossi, M.
Arnold, D.
Castelo-Branco, L.
Harrington, K. J.
Michielin, O. A.
Pentheroudakis, G.
Peters, S.
Affiliation
Medical Oncology Department, Institut Curie, Paris, FranceIssue Date
2021
Metadata
Show full item recordAbstract
Background At the height of the first wave of the SARS-COV-2 pandemic, ESMO mobilized to accelerate research for the understanding of COVID-19 in cancer patients (pts). ESMO CoCARE is an international collaborative registry-based, cohort study, gathering real-world data and information from healthcare professionals about the natural history, treatment and outcomes of COVID-19 in cancer pts. Methods ESMO CoCARE captures information on pts with any solid or hematologic malignancy (including cancer survivors free of disease for ?5 years) presenting with a COVID-19 diagnosis in any of the participating centers. Data collected since 06/2020 include demographics, cancer characteristics and status, co-morbidities, COVID-19 clinical features, course, management and outcome. Factors influencing COVID-19 severity (hospitalization +/- ICU support needed) and recovery are investigated using multivariable logistic regression with backward elimination method. The study is ongoing. Results The current analysis includes 1551 registered pts (19 countries; 87% pts from 23 European centers, 7% and 6% pts from 5 Northern African and 7 Asian centers), with COVID-19 diagnosis as of 11/03/2021. Median age was 64 years, with the majority female (52%), cancer stage III/IV (58%), and on active cancer treatment (60%). 65% had severe COVID-19 requiring hospitalization, with 11% receiving intensive care. In multivariable analysis, in addition to demographics (male gender, older age, other ethnicity than Caucasian, lower BMI), co-morbidities and symptomatic COVID-19, severe disease was associated to higher ECOG PS (Odds Ratio (OR)2 vs 0=5.9, OR1 vs 0=2.1), hematological malignancies (OR hemvs solid =2.0), and active/progressive cancer status (OR progressivevs no evidence of disease =1.6). 98% of pts with mild disease recovered, as opposed to only 70% of those with severe disease. Cancer stage was an additional prognostic factor for recovery (ORI/II vs IV =3.4). Conclusions Demographic characteristics, type and status of cancer, and symptomatology of COVID-19 increase the probability of severe disease, while advanced cancer stage is also associated with the risk of death.Citation
Romano E, Gennatas S, Rogado J, Sekacheva M, Vi�al D, Lee R, et al. 1567MO COVID-19 and cancer: First report of the ESMO international, registry-based, cohort study (ESMO CoCARE). Vol. 32, Annals of Oncology. Elsevier BV; 2021. p. S1133.Journal
Annals of OncologyDOI
10.1016/j.annonc.2021.08.1560Additional Links
https://dx.doi.org/10.1016/j.annonc.2021.08.1560Type
OtherLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.annonc.2021.08.1560