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    Pancreaticobiliary malignancies in the emergency room: management of acute complications and oncological emergencies

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    Authors
    Kamposioras, Konstantinos
    Geraghty, J.
    Appleyard, J.
    Dawod, M.
    Papadimitriou, K.
    Lamarca, Angela
    Anthoney, A.
    Affiliation
    The Christie NHS Foundation Trust, Manchester, Greater Manchester, UK
    Issue Date
    2021
    
    Metadata
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    Abstract
    Background: Management of pancreaticobiliary (PB) malignancies remains a clinical challenge. In this review, we focus on the management of oncological emergencies in PB malignancies and the potential complication of associated therapeutic interventions. Methods: Biobliographic review of current evidence on the management of oncological emergencies, their potential complications, as well as synthesis of recommendations was performed. The pathogenesis, frequency, related symptoms as well as appropriate investigations are presented. Results: The oncologic emergencies in PB patients were summarised in six categories: (1) hematological (including febrile neutropaenia, thrombocytopenia, coagulopathies), (2) gastrointestinal (gastric outlet and biliary obstruction, gastrointestinal bleeding), (3) thromboembolic events, (4) ascites, (5) metabolic disorders and (6) neurologic complications. The pathogenesis, frequency, related symptoms as well as appropriate investigations are also presented. Conclusion: Patients with PB malignancies are at increased risk of a wide variation of medical emergencies. Clinical knowledge, early recognition and collaboration with the relevant specialties are critical to manage these complications effectively, tailoring overall management around the actual prognosis and individuals' expectations.
    Citation
    Kamposioras K, Geraghty J, Appleyard J, Dawod M, Papadimitriou K, Lamarca A, et al. Pancreaticobiliary Malignancies in the Emergency Room: Management of Acute Complications and Oncological Emergencies. Journal of Gastrointestinal Cancer. Springer Science and Business Media LLC; 2021.
    Journal
    Journal of Gastrointestinal Cancer
    URI
    http://hdl.handle.net/10541/624685
    DOI
    10.1007/s12029-021-00718-7
    PubMed ID
    34648136
    Additional Links
    https://dx.doi.org/10.1007/s12029-021-00718-7
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12029-021-00718-7
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