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    HE4 as a biomarker for endometrial cancer

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    Authors
    Behrouzi, Roya
    Barr, C. E.
    Crosbie, E. J.
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    There are currently no blood biomarkers in routine clinical use in endometrial carcinoma (EC). Human epididymis protein 4 (HE4) is a glycoprotein that is overexpressed in the serum of patients with EC, making it a good candidate for use as a diagnostic and/or prognostic biomarker. HE4 is correlated with poor prognostic factors, including stage, myometrial invasion and lymph node metastases, which means it could be used to guide decisions regarding the extent of surgery and need for adjuvant therapy. Serum HE4 has also shown promise for predicting responses to progestin therapy in early-stage EC. The use of algorithms and indices incorporating serum HE4 and other biomarkers, including clinical and imaging variables, is an area of increasing interest. Serum HE4 levels rise with age and renal dysfunction, which may affect the interpretation of results. This review covers the evidence supporting the use of HE4 as an EC biomarker for diagnosis, prognosis, recurrence monitoring, and prediction of therapy response. The evidence for combining serum HE4 with other biomarkers, including clinical and imaging variables, its value as a biomarker in other biofluids and potential challenges of its clinical use are also discussed.
    Citation
    Behrouzi R, Barr CE, Crosbie EJ. HE4 as a Biomarker for Endometrial Cancer. Vol. 13, Cancers. MDPI AG; 2021. p. 4764.
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/624682
    DOI
    10.3390/cancers13194764
    PubMed ID
    34638250
    Additional Links
    https://dx.doi.org/10.3390/cancers13194764
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers13194764
    Scopus Count
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