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dc.contributor.authorShotton, Rohan
dc.contributor.authorLamarca, Angela
dc.contributor.authorValle, Juan W
dc.contributor.authorMcNamara, Mairead G
dc.date.accessioned2021-10-28T09:26:05Z
dc.date.available2021-10-28T09:26:05Z
dc.date.issued2021en
dc.identifier.citationShotton R, Lamarca A, Valle J, McNamara MG. Potential utility of liquid biopsies in the management of patients with biliary tract cancers: A review. Vol. 13, World Journal of Gastrointestinal Oncology. Baishideng Publishing Group Inc.; 2021. p. 1073�85.en
dc.identifier.pmid34616513en
dc.identifier.doi10.4251/wjgo.v13.i9.1073en
dc.identifier.urihttp://hdl.handle.net/10541/624679
dc.description.abstractBiliary tract cancer, comprising gallbladder cancer, cholangiocarcinoma and ampullary cancer, represents a more uncommon entity outside high-endemic areas, though global incidence is rising. The majority of patients present at a late stage, and 5-year survival remains poor. Advanced stage disease is incurable, and though palliative chemotherapy has been shown to improve survival, further diagnostic and therapeutic options are required in order to improve patient outcomes. Although certain subtypes of biliary tract cancer are relatively rich in targetable mutations, attaining tumour tissue for histological diagnosis and treatment monitoring is challenging due to locoregional anatomical constraints and patient fitness. Liquid biopsies offer a safe and convenient alternative to invasive procedures and have great potential as diagnostic, predictive and prognostic biomarkers. In this review, the current standard of care for patients with biliary tract cancer, future treatment horizons and the possible utility of liquid biopsies within a variety of contexts will be discussed. Circulating tumour DNA, circulating microRNA and circulating tumour cells are discussed with an overview of their potential applications in management of biliary tract cancer. A summary is also provided of currently recruiting clinical trials incorporating liquid biopsies within biliary tract cancer research.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.4251/wjgo.v13.i9.1073en
dc.titlePotential utility of liquid biopsies in the management of patients with biliary tract cancers: A reviewen
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BXen
dc.identifier.journalWorld Journal of Gastrointestinal Oncologyen
dc.description.noteen]
refterms.dateFOA2021-11-03T09:00:00Z


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