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    Potential utility of liquid biopsies in the management of patients with biliary tract cancers: A review

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    Authors
    Shotton, Rohan
    Lamarca, Angela
    Valle, Juan W
    McNamara, Mairead G
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX
    Issue Date
    2021
    
    Metadata
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    Abstract
    Biliary tract cancer, comprising gallbladder cancer, cholangiocarcinoma and ampullary cancer, represents a more uncommon entity outside high-endemic areas, though global incidence is rising. The majority of patients present at a late stage, and 5-year survival remains poor. Advanced stage disease is incurable, and though palliative chemotherapy has been shown to improve survival, further diagnostic and therapeutic options are required in order to improve patient outcomes. Although certain subtypes of biliary tract cancer are relatively rich in targetable mutations, attaining tumour tissue for histological diagnosis and treatment monitoring is challenging due to locoregional anatomical constraints and patient fitness. Liquid biopsies offer a safe and convenient alternative to invasive procedures and have great potential as diagnostic, predictive and prognostic biomarkers. In this review, the current standard of care for patients with biliary tract cancer, future treatment horizons and the possible utility of liquid biopsies within a variety of contexts will be discussed. Circulating tumour DNA, circulating microRNA and circulating tumour cells are discussed with an overview of their potential applications in management of biliary tract cancer. A summary is also provided of currently recruiting clinical trials incorporating liquid biopsies within biliary tract cancer research.
    Citation
    Shotton R, Lamarca A, Valle J, McNamara MG. Potential utility of liquid biopsies in the management of patients with biliary tract cancers: A review. Vol. 13, World Journal of Gastrointestinal Oncology. Baishideng Publishing Group Inc.; 2021. p. 1073�85.
    Journal
    World Journal of Gastrointestinal Oncology
    URI
    http://hdl.handle.net/10541/624679
    DOI
    10.4251/wjgo.v13.i9.1073
    PubMed ID
    34616513
    Additional Links
    https://dx.doi.org/10.4251/wjgo.v13.i9.1073
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.4251/wjgo.v13.i9.1073
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