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    Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy

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    Authors
    Wheatley, Roseanna
    Kilgour, Elaine
    Jacobs, Timothy
    Lamarca, Angela
    Hubner, Richard A
    Valle, Juan W
    McNamara, Mairead G
    Affiliation
    Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester
    Issue Date
    2021
    
    Metadata
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    Abstract
    Biliary tract cancers, including intra- and extra-hepatic cholangiocarcinoma as well as gallbladder cancer, are associated with poor prognosis and the majority of patients present with advanced-stage, non-resectable disease at diagnosis. Biliary tract cancer may develop through an accumulation of genetic and epigenetic alterations and can be influenced by microbial exposure. Furthermore, the liver and biliary tract are exposed to the gastrointestinal microbiome through the gut-liver axis. The availability of next-generation sequencing technology has led to an increase in studies investigating the relationship between microbiota and human disease. In particular, the interplay between the microbiome, the tumour micro-environment and response to systemic therapy is a prospering area of interest. Given the poor outcomes for patients with biliary tract cancer, this emerging field of research, through which new biomarkers may be identified, offers potential as a tool for early diagnosis, prognostication or even as a future therapeutic target. This review summarises the available evidence on the microbiome environment in patients with biliary tract cancer, including a discussion around confounding factors, implications for therapy and proposed future directions.
    Citation
    Wheatley RC, Kilgour E, Jacobs T, Lamarca A, Hubner RA, Valle JW, et al. Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy. British Journal of Cancer. Springer Science and Business Media LLC; 2021.
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/624661
    DOI
    10.1038/s41416-021-01583-8
    PubMed ID
    34663949
    Additional Links
    https://dx.doi.org/10.1038/s41416-021-01583-8
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-021-01583-8
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