Show simple item record

dc.contributor.authorBroadbent, Rachel
dc.contributor.authorWheatley, Roseanna
dc.contributor.authorStajer, S.
dc.contributor.authorJacobs, Timothy
dc.contributor.authorLamarca, Angela
dc.contributor.authorHubner, Richard A
dc.contributor.authorValle, Juan W
dc.contributor.authorAmir, E.
dc.contributor.authorMcNamara, Mairead G
dc.date.accessioned2021-10-28T09:26:01Z
dc.date.available2021-10-28T09:26:01Z
dc.date.issued2021en
dc.identifier.citationBroadbent R, Wheatley R, Stajer S, Jacobs T, Lamarca A, Hubner RA, et al. Prognostic factors for relapse in resected gastroenteropancreatic neuroendocrine neoplasms: A systematic review and meta-analysis. Vol. 101, Cancer Treatment Reviews. Elsevier BV; 2021. p. 102299.en
dc.identifier.pmid34662810en
dc.identifier.doi10.1016/j.ctrv.2021.102299en
dc.identifier.urihttp://hdl.handle.net/10541/624660
dc.description.abstractBackground: Gastroenteropancreatic neoplasms (GEP-NENs)can potentially be cured through surgical resection, but only 42-57% achieve 5-year disease-free survival.There is a lack of consensus regarding the factorsassociated withrelapse followingresection ofGEP-NENs. Methods: Asystematic review identified studies reporting factors associated with relapse in patients with GEP-NENs following resection of a primary tumour. Meta-analysis was performed to identify the factors prognostic for relapse-free survival (RFS)oroverall survival (OS). Results: 63 studies comprising 13,715 patients were included; 56 studies reported on pancreatic NENs (12,418 patients), 24 reported on patients with grade 1-2 tumours (4,735 patients). Median follow-up was 44.2 months, median RFS was 32 months. Pooling of multivariable analyses of GEP-NENs (all sites and grades) found the following factors predicted worse RFS (all p values < 0.05): vascular resection performed, metastatic disease resected, grade 2 disease, grade 3 disease, tumour size > 20 mm, R1 resection, microvascular invasion, perineural invasion, Ki-67 > 5% and any lymph node positivity. In a subgroup of studies comprising exclusively of grade 1-2 GEP-NENs, R1 resection, perineural invasion, grade 2 disease, any lymph node positivity and tumour size > 20 mm predicted worse RFS (all p values < 0.05). Few OSdata were available for pooling; in univariableanalysis(entire cohort), grade 2 predicted worse OS (p = 0.007), whileR1 resectiondid not (p = 0.14). Conclusions: The factors prognostic for worse RFS following resection of a GEP-NEN identified in this meta-analysis could be included in post-curative treatment surveillance clinical guidelines and inform the stratification and inclusion criteria of future adjuvant trials.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.ctrv.2021.102299en
dc.titlePrognostic factors for relapse in resected gastroenteropancreatic neuroendocrine neoplasms: A systematic review and meta-analysisen
dc.typeArticleen
dc.contributor.departmentUniversity of Manchester, Division of Cancer Sciences, Manchester M20 4BX, UK; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BXen
dc.identifier.journalCancer Treatment Reviewsen
dc.description.noteen]


Files in this item

This item appears in the following Collection(s)

Show simple item record