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dc.contributor.authorDatta, Anubhav
dc.contributor.authorWest, Catharine M L
dc.contributor.authorO'Connor, James P B
dc.contributor.authorChoudhury, Ananya
dc.contributor.authorHoskin, Peter J
dc.date.accessioned2021-10-28T09:26:00Z
dc.date.available2021-10-28T09:26:00Z
dc.date.issued2021en
dc.identifier.citationDatta A, West C, O�Connor JPB, Choudhury A, Hoskin P. Impact of hypoxia on cervical cancer outcomes. International Journal of Gynecologic Cancer. BMJ; 2021. p. ijgc�2021�002806.en
dc.identifier.pmid34593564en
dc.identifier.doi10.1136/ijgc-2021-002806en
dc.identifier.urihttp://hdl.handle.net/10541/624658
dc.description.abstractThe annual global incidence of cervical cancer is approximately 604 000 cases/342 000 deaths, making it the fourth most common cancer in women. Cervical cancer is a major healthcare problem in low and middle income countries where 85% of new cases and deaths occur. Secondary prevention measures have reduced incidence and mortality in developed countries over the past 30 years, but cervical cancer remains a major cause of cancer deaths in women. For women who present with F�d�ration Internationale de Gyn�cologie et d'Obst�trique (FIGO 2018) stages IB3 or upwards, chemoradiation is the established treatment. Despite high rates of local control, overall survival is less than 50%, largely due to distant relapse. Reducing the health burden of cervical cancer requires greater individualization of treatment, identifying those at risk of relapse and progression for modified or intensified treatment. Hypoxia is a well known feature of solid tumors and an established therapeutic target. Low tumorous oxygenation increases the risk of local invasion, metastasis and treatment failure. While meta-analyses show benefit, many individual trials targeting hypoxia failed in part due to not selecting patients most likely to benefit. This review summarizes the available hypoxia-targeted strategies and identifies further research and new treatment paradigms needed to improve patient outcomes. The applications and limitations of hypoxia biomarkers for treatment selection and response monitoring are discussed. Finally, areas of greatest unmet clinical need are identified to measure and target hypoxia and therefore improve cervical cancer outcomes.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1136/ijgc-2021-002806en
dc.titleImpact of hypoxia on cervical cancer outcomesen
dc.typeArticleen
dc.contributor.departmentDivision of Cancer Sciences, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UKen
dc.identifier.journalInternational Journal of Gynecological Canceren
dc.description.noteen]


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