Affiliation
Division of Cancer Sciences, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UKIssue Date
2021
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Show full item recordAbstract
The annual global incidence of cervical cancer is approximately 604 000 cases/342 000 deaths, making it the fourth most common cancer in women. Cervical cancer is a major healthcare problem in low and middle income countries where 85% of new cases and deaths occur. Secondary prevention measures have reduced incidence and mortality in developed countries over the past 30 years, but cervical cancer remains a major cause of cancer deaths in women. For women who present with F�d�ration Internationale de Gyn�cologie et d'Obst�trique (FIGO 2018) stages IB3 or upwards, chemoradiation is the established treatment. Despite high rates of local control, overall survival is less than 50%, largely due to distant relapse. Reducing the health burden of cervical cancer requires greater individualization of treatment, identifying those at risk of relapse and progression for modified or intensified treatment. Hypoxia is a well known feature of solid tumors and an established therapeutic target. Low tumorous oxygenation increases the risk of local invasion, metastasis and treatment failure. While meta-analyses show benefit, many individual trials targeting hypoxia failed in part due to not selecting patients most likely to benefit. This review summarizes the available hypoxia-targeted strategies and identifies further research and new treatment paradigms needed to improve patient outcomes. The applications and limitations of hypoxia biomarkers for treatment selection and response monitoring are discussed. Finally, areas of greatest unmet clinical need are identified to measure and target hypoxia and therefore improve cervical cancer outcomes.Citation
Datta A, West C, O�Connor JPB, Choudhury A, Hoskin P. Impact of hypoxia on cervical cancer outcomes. International Journal of Gynecologic Cancer. BMJ; 2021. p. ijgc�2021�002806.Journal
International Journal of Gynecological CancerDOI
10.1136/ijgc-2021-002806PubMed ID
34593564Additional Links
https://dx.doi.org/10.1136/ijgc-2021-002806Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1136/ijgc-2021-002806