• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Role of postoperative radiotherapy in the management for resected NSCLC - decision criteria in clinical routine pre- and post-lungART

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Süveg, K.
    Le Pechoux, C.
    Faivre-Finn, Corinne
    Putora, P. M.
    De Ruysscher, D
    Widder, J.
    Van Houtte, P.
    Troost, E. G. C.
    Slotman, B. J.
    Ramella, S.
    Pöttgen, C.
    Peeters, S. T. H.
    Nestle, U.
    McDonald, F.
    Dziadziuszko, R.
    Belderbos, J.
    Ricardi, U.
    Manapov, F.
    Lievens, Y.
    Geets, X.
    Dieckmann, K.
    Guckenberger, M.
    Andratschke, N.
    Glatzer, M.
    Show allShow less
    Affiliation
    Department of Radiation Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Background: The role of postoperative radiation therapy (PORT) in stage III N2 NSCLC is controversial. We analyzed decision-making for PORT among European radiation oncology experts in lung cancer. Methods: Twenty-two experts were asked before and after presentation of the results of the LungART trial to describe their decision criteria for PORT in the management of pN+ NSCLC patients. Treatment strategies were subsequently converted into decision trees and analyzed. Results: Following decision criteria were identified: extracapsular nodal extension, incomplete lymph node resection, multistation lymph nodes, high nodal tumor load, poor response to induction chemotherapy, ineligibility to receive adjuvant chemotherapy, performance status, resection margin, lung function and cardiopulmonary comorbidities. The LungART results had impact on decision-making and reduced the number of recommendations for PORT. The only clear indication for PORT was a R1/2 resection. Six experts out of ten who initially recommended PORT for all R0 resected pN2 patients no longer used PORT routinely for these patients, while four still recommended PORT for all patients with pN2. Fourteen experts used PORT only for patients with risk factors, compared to eleven before the presentation of the LungART trial. Four experts stated that PORT was never recommended in R0 resected pN2 patients regardless of risk factors. Conclusion: After presentation of the LungART trial results at ESMO 2020, 82% of our experts still used PORT for stage III pN2 NSCLC patients with risk factors. The recommendation for PORT decreased, especially for patients without risk factors. Cardiopulmonary comorbidities became more relevant in the decision-making for PORT.
    Citation
    Süveg K, Le Pechoux C, Faivre-Finn C, Putora PM, De Ruysscher D, Widder J, et al. Role of Postoperative Radiotherapy in the Management for Resected NSCLC – Decision Criteria in Clinical Routine Pre- and Post-LungART. Clinical Lung Cancer. 2021 Aug.
    Journal
    Clinical Lung Cancer
    URI
    http://hdl.handle.net/10541/624613
    DOI
    10.1016/j.cllc.2021.08.007
    PubMed ID
    34538585
    Additional Links
    https://dx.doi.org/10.1016/j.cllc.2021.08.007
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cllc.2021.08.007
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Real world practice of postoperative radiotherapy for patients with completely resected pIIIA-N2 non-small cell lung cancer: a national survey of radiation oncologists in China.
    • Authors: Zhou S, Zhai Y, Zhao K, Men Y, Meng X, Hui Z
    • Issue date: 2023 Jan 25
    • Role of Adjuvant Radiotherapy in Non-Small Cell Lung Cancer-A Review.
    • Authors: Süveg K, Plasswilm L, Iseli T, Leskow P, Fischer GF, Putora PM
    • Issue date: 2022 Mar 23
    • Prognostic factors for resected non-small cell lung cancer with pN2 status: implications for use of postoperative radiotherapy.
    • Authors: Moretti L, Yu DS, Chen H, Carbone DP, Johnson DH, Keedy VL, Putnam JB Jr, Sandler AB, Shyr Y, Lu B
    • Issue date: 2009 Nov
    • Use of adjuvant chemotherapy (CT) and radiotherapy (RT) in incompletely resected (R1) early stage Non-Small Cell Lung Cancer (NSCLC): a European survey conducted by the European Society for Medical Oncology (ESMO) young oncologists committee.
    • Authors: Califano R, Karamouzis MV, Banerjee S, de Azambuja E, Guarneri V, Hutka M, Jordan K, Kamposioras K, Martinelli E, Corral J, Postel-Vinay S, Preusser M, Porcu L, Torri V
    • Issue date: 2014 Jul
    • Choice of postoperative radiation for stage IIIA pathologic N2 non-small cell lung cancer: impact of metastatic lymph node number.
    • Authors: Wang S, Ma Z, Yang X, Wang Y, Xu Y, Xia W, Chen R, Qiu M, Jiang F, Yin R, Xu L, Xu K
    • Issue date: 2017 Dec 29
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.