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dc.contributor.authorIllidge, Timothy M
dc.contributor.authorPhillips, Elizabeth H
dc.date.accessioned2021-09-30T11:56:04Z
dc.date.available2021-09-30T11:56:04Z
dc.date.issued2021en
dc.identifier.citationllidge TM, Phillips EH. Progress and pitfalls with the use of image-guided personalised approaches in lymphoma. BJR. 2021 Sep 14;20210609.en
dc.identifier.pmid34520671en
dc.identifier.doi10.1259/bjr.20210609en
dc.identifier.urihttp://hdl.handle.net/10541/624607
dc.description.abstractThe use of 18F-FDG PET CT has become an essential part of the management of patients with lymphoma. The last decade has seen unrivalled progress in research efforts to personalise treatment approaches using PET as a predictive imaging biomarker. Critical to this success has been the standardisation of PET methods and reporting, including the 5-point Deauville scale, which has enabled the delivery of robust clinical trial data to develop response-adapted treatment approaches.(1, 2) The utility of PET as a predictive imaging biomarker in assessing treatment success or failure has been investigated extensively in malignant lymphomas. Considerable progress has been made over the last decade, in using PET to direct more personalised "risk-adapted" approaches, as well as an increased understanding of some of the limitations. Arguably the greatest success has been in Hodgkin Lymphoma (HL) where PET was initially demonstrated to be a powerful predictive biomarker (3) and is now routinely used in both early-stage and advanced HL to reduce or escalate the use of chemotherapy as well as guiding the delivery of more selective radiotherapy to patients.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1259/bjr.20210609en
dc.titleProgress and pitfalls with the use of image-guided personalised approaches in lymphomaen
dc.typeArticleen
dc.contributor.departmentDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, NIHR Biomedical Research Centre, Manchester Academic Health Sciences Centre, Christie Hospital NHS Foundation Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Radiologyen
dc.description.noteen]


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