• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    A practical approach to bladder preservation with hypofractionated radiotherapy for localised muscle-invasive bladder cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    34466667.pdf
    Size:
    834.1Kb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Portner, Robin
    Bajaj, A.
    Elumalai, Thiraviyam
    Huddart, R.
    Murthy, V.
    Nightingale, Hannah
    Patel, Kamlesh
    Sargos, P.
    Song, Yee Pei
    Hoskin, Peter J
    Choudhury, Ananya
    Show allShow less
    Affiliation
    The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Bladder preservation with trimodality treatment (TMT) is an alternative strategy to radical cystectomy (RC) for the management of localised muscle invasive bladder cancer (MIBC). TMT comprises of transurethral resection of the bladder tumour (TURBT) followed by radiotherapy with concurrent radiosensitisation. TMT studies have shown neo-adjuvant chemotherapy with cisplatin-based regimens is often given to further improve survival outcomes. A hypofractionated radiotherapy regimen is preferable due to its non-inferiority in local control and late toxicities. Radiosensitisation can comprise concurrent chemotherapy (with gemcitabine, cisplatin or combination fluorouracil and mitomycin), CON (carbogen and nicotinomide) or hyperthermic treatment. Radiotherapy techniques are continuously improving and becoming more personalised. As the bladder is a mobile structure subject to volumetric changes from filling, an adaptive approach can optimise bladder coverage and reduce dose to normal tissue. Adaptive radiotherapy (ART) is an evolving field that aims to overcome this. Improved knowledge of tumour biology and advances in imaging techniques aims to further optimise and personalise treatment.
    Citation
    Portner R, Bajaj A, Elumalai T, Huddart R, Murthy V, Nightingale H, et al. A practical approach to bladder preservation with hypofractionated radiotherapy for localised muscle-invasive bladder cancer. Clinical and Translational Radiation Oncology. 2021 Nov;31:1–7.
    Journal
    Clinical and Translational Radiation Oncology
    URI
    http://hdl.handle.net/10541/624570
    DOI
    10.1016/j.ctro.2021.08.003
    PubMed ID
    34466667
    Additional Links
    https://dx.doi.org/10.1016/j.ctro.2021.08.003
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctro.2021.08.003
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Radical cystectomy versus organ-sparing trimodality treatment in muscle-invasive bladder cancer: A systematic review of clinical trials.
    • Authors: Arcangeli G, Strigari L, Arcangeli S
    • Issue date: 2015 Sep
    • Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: a systematic review.
    • Authors: Ploussard G, Daneshmand S, Efstathiou JA, Herr HW, James ND, Rödel CM, Shariat SF, Shipley WU, Sternberg CN, Thalmann GN, Kassouf W
    • Issue date: 2014 Jul
    • Comparison of outcomes between trimodal therapy and radical cystectomy in muscle-invasive bladder cancer: a propensity score matching analysis.
    • Authors: Kim YJ, Byun SJ, Ahn H, Kim CS, Hong BS, Yoo S, Lee JL, Kim YS
    • Issue date: 2017 Sep 15
    • Transurethral Resection of Bladder Tumor (TUR-BT) then Concomitant Radiation and Cisplatin Followed by Adjuvant Gemcitabine and Cisplatin in Muscle Invasive Transitional Cell Carcinoma (TCC) of the Urinary Bladder.
    • Authors: Ibrahim SM, Abd El-Hafeez ZM, Mohamed EM, Elsharawy IA, Kamal KM
    • Issue date: 2007 Mar
    • Patterns of Bladder Preservation Therapy Utilization for Muscle-Invasive Bladder Cancer.
    • Authors: Rose TL, Deal AM, Ladoire S, Créhange G, Galsky MD, Rosenberg JE, Bellmunt J, Wimalasingham A, Wong YN, Harshman LC, Chowdhury S, Niegisch G, Liontos M, Yu EY, Pal SK, Chen RC, Wang AZ, Nielsen ME, Smith AB, Milowsky MI, Retrospective International Study of Cancers of the Urothelial Tract (RISC) Investigators
    • Issue date: 2016 Oct 27
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.