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dc.contributor.authorMariam, N. B. G.
dc.contributor.authorSong, Yee Pei
dc.contributor.authorJoseph, Nuradh
dc.contributor.authorHoskin, Peter J
dc.contributor.authorReeves, Kimberley J
dc.contributor.authorPorta, N.
dc.contributor.authorJames, N.
dc.contributor.authorChoudhury, Ananya
dc.date.accessioned2021-09-30T11:55:56Z
dc.date.available2021-09-30T11:55:56Z
dc.date.issued2021en
dc.identifier.citationMariam NBG, Song YP, Joseph N, Hoskin P, Reeves K, Porta N, et al. Hypofractionation: less is more? Oncotarget. 2021 Aug 17;12(17):1729–33.en
dc.identifier.pmid34434502en
dc.identifier.doi10.18632/oncotarget.28023en
dc.identifier.urihttp://hdl.handle.net/10541/624568
dc.description.abstractOne third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. In the UK, both conventional fractionation with 64 Gy in 32 fractions and hypofractionation with 55 Gy in 20 fractions are standard of care options with the choice varying between centres. A meta-analysis of individual patients with locally advanced bladder cancer from two UK multicentre phase 3 trials was published recently. This study evaluated the non-inferiority of a hypofractionated schedule compared to a conventional regime. This analysis confirmed the non-inferiority of the hypofractionated regimen, and noted superior locoregional control. We discuss the relevance of these findings to current practice while considering the radiobiology of hypofractionation, the role of systemic therapies and radiosensitisation, as well as the socioeconomic benefits.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.18632/oncotarget.28023en
dc.titleHypofractionation: less is more?en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UKen
dc.identifier.journalOncotargeten
dc.description.noteen]
refterms.dateFOA2021-10-13T07:21:30Z


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