Authors
Mariam, N. B. G.Song, Yee Pei
Joseph, Nuradh
Hoskin, Peter J
Reeves, Kimberley J
Porta, N.
James, N.
Choudhury, Ananya
Affiliation
Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UKIssue Date
2021
Metadata
Show full item recordAbstract
One third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. In the UK, both conventional fractionation with 64 Gy in 32 fractions and hypofractionation with 55 Gy in 20 fractions are standard of care options with the choice varying between centres. A meta-analysis of individual patients with locally advanced bladder cancer from two UK multicentre phase 3 trials was published recently. This study evaluated the non-inferiority of a hypofractionated schedule compared to a conventional regime. This analysis confirmed the non-inferiority of the hypofractionated regimen, and noted superior locoregional control. We discuss the relevance of these findings to current practice while considering the radiobiology of hypofractionation, the role of systemic therapies and radiosensitisation, as well as the socioeconomic benefits.Citation
Mariam NBG, Song YP, Joseph N, Hoskin P, Reeves K, Porta N, et al. Hypofractionation: less is more? Oncotarget. 2021 Aug 17;12(17):1729–33.Journal
OncotargetDOI
10.18632/oncotarget.28023PubMed ID
34434502Additional Links
https://dx.doi.org/10.18632/oncotarget.28023Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.18632/oncotarget.28023
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