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dc.contributor.authorGrytsai, Oleksandr
dc.contributor.authorMyrgorodska, I.
dc.contributor.authorRocchi, S.
dc.contributor.authorRonco, C
dc.contributor.authorBenhida, R.
dc.date.accessioned2021-09-07T13:16:21Z
dc.date.available2021-09-07T13:16:21Z
dc.date.issued2021en
dc.identifier.citationGrytsai O, Myrgorodska I, Rocchi S, Ronco C, Benhida R. Biguanides drugs: Past success stories and promising future for drug discovery. European Journal of Medicinal Chemistry. 2021 Nov;224:113726.en
dc.identifier.pmid34364161en
dc.identifier.doi10.1016/j.ejmech.2021.113726en
dc.identifier.urihttp://hdl.handle.net/10541/624556
dc.description.abstractBiguanides have attracted much attention a century ago and showed resurgent interest in recent years after a long period of dormancy. They constitute an important class of therapeutic agents suitable for the treatment of a wide spectrum of diseases. Therapeutic indications of biguanides include antidiabetic, antimalarial, antiviral, antiplaque, and bactericidal applications. This review presents an extensive overview of the biological activity of biguanides and different mechanisms of action of currently marketed biguanide-containing drugs, as well as their pharmacological properties when applicable. We highlight the recent developments in research on biguanide compounds, with a primary focus on studies on metformin in the field of oncology. We aim to provide a critical overview of all main bioactive biguanide compounds and discuss future perspectives for the design of new drugs based on the biguanide fragment.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.ejmech.2021.113726en
dc.titleBiguanides drugs: Past success stories and promising future for drug discoveryen
dc.typeArticleen
dc.contributor.departmentUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice UMR 7272, 28 Avenue Valrose, 06108, Nice, France; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, SK10 4TG,en
dc.identifier.journalEuropean Journal of Medicinal Chemistryen
dc.description.noteen]


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