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    Biguanides drugs: Past success stories and promising future for drug discovery

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    Authors
    Grytsai, Oleksandr
    Myrgorodska, I.
    Rocchi, S.
    Ronco, C
    Benhida, R.
    Affiliation
    Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR 7272, 28 Avenue Valrose, 06108, Nice, France; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, SK10 4TG,
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Biguanides have attracted much attention a century ago and showed resurgent interest in recent years after a long period of dormancy. They constitute an important class of therapeutic agents suitable for the treatment of a wide spectrum of diseases. Therapeutic indications of biguanides include antidiabetic, antimalarial, antiviral, antiplaque, and bactericidal applications. This review presents an extensive overview of the biological activity of biguanides and different mechanisms of action of currently marketed biguanide-containing drugs, as well as their pharmacological properties when applicable. We highlight the recent developments in research on biguanide compounds, with a primary focus on studies on metformin in the field of oncology. We aim to provide a critical overview of all main bioactive biguanide compounds and discuss future perspectives for the design of new drugs based on the biguanide fragment.
    Citation
    Grytsai O, Myrgorodska I, Rocchi S, Ronco C, Benhida R. Biguanides drugs: Past success stories and promising future for drug discovery. European Journal of Medicinal Chemistry. 2021 Nov;224:113726.
    Journal
    European Journal of Medicinal Chemistry
    URI
    http://hdl.handle.net/10541/624556
    DOI
    10.1016/j.ejmech.2021.113726
    PubMed ID
    34364161
    Additional Links
    https://dx.doi.org/10.1016/j.ejmech.2021.113726
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejmech.2021.113726
    Scopus Count
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    All Paterson Institute for Cancer Research

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