Regulatory and functional involvement of long non-coding RNAs in DNA double-strand break repair mechanisms
AffiliationMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece.
MetadataShow full item record
AbstractProtection of genome integrity is vital for all living organisms, particularly when DNA double-strand breaks (DSBs) occur. Eukaryotes have developed two main pathways, namely Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR), to repair DSBs. While most of the current research is focused on the role of key protein players in the functional regulation of DSB repair pathways, accumulating evidence has uncovered a novel class of regulating factors termed non-coding RNAs. Non-coding RNAs have been found to hold a pivotal role in the activation of DSB repair mechanisms, thereby safeguarding genomic stability. In particular, long non-coding RNAs (lncRNAs) have begun to emerge as new players with vast therapeutic potential. This review summarizes important advances in the field of lncRNAs, including characterization of recently identified lncRNAs, and their implication in DSB repair pathways in the context of tumorigenesis.
CitationPapaspyropoulos A, Lagopati N, Mourkioti I, Angelopoulou A, Kyriazis S, Liontos M, et al. Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms. Cells. 2021 Jun 15;10(6):1506.
- Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs.
- Authors: Thapar R
- Issue date: 2018 Oct 27
- The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks.
- Authors: Dianatpour A, Ghafouri-Fard S
- Issue date: 2017 Winter
- Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.
- Authors: Grabarz A, Barascu A, Guirouilh-Barbat J, Lopez BS
- Issue date: 2012
- Mechanisms of DNA double strand break repair and chromosome aberration formation.
- Authors: Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G
- Issue date: 2004
- Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining.
- Authors: Helfricht A, Wiegant WW, Thijssen PE, Vertegaal AC, Luijsterburg MS, van Attikum H
- Issue date: 2013 Sep 15