Authors
Gaudy-Marqueste, C.Macagno, N.
Loundou, A.
Pellegrino, E.
Ouafik, L.
Budden, Timothy
Mundra, Piyashkumar A
Gremel, Gabriela
Akhras, V.
Lin, L.
Cook, Martin G
Kumar, R.
Grob, J. J.
Nagore, E.
Marais, Richard
Virós, Amaya
Affiliation
Aix Marseille Univ, APHM, CRCM Inserm U1068, CNRS U7258, CHU Timone, Dermatology and Skin Cancer Department, Marseille, France.Issue Date
2021
Metadata
Show full item recordAbstract
Background: The rate of growth of primary melanoma is a robust predictor of aggressiveness, but the mutational profile of fast-growing melanomas (FGMM), and its potential to stratify patients at high risk of death, has not been comprehensively studied. Objective: To investigate the epidemiological, clinical and mutational profile of primary cutaneous melanomas with a thickness ≥ 1mm, stratified by rate of growth (ROG). Methods: Observational prospective study. Deep-targeted sequencing of 40 melanoma driver genes on formalin fixed, paraffin embedded primary melanoma samples. Comparison of FGMM (ROG >0.5mm/month) and non-FGMM (ROG≤0.5 mm/month). Results: Two hundred patients were enrolled among which 70 were FGMM. The relapse free survival was lower in the FGMM group (p=0.014). FGMM had a higher number of predicted deleterious mutations within the 40 genes than non-FGMM (p=0.033). Ulceration (p=0.032), thickness (p=0.006), lower sun exposure (p=0.049), and FGFR2 mutations (p=0.037) were significantly associated with fast growth. Limitations: Single-center study, cohort size, potential memory bias, number of investigated genes. Conclusion: Fast growth is linked to specific tumor biology and environmental factors. Ulceration, thickness and FGFR2 mutations associate with fast growth. Screening for FGFR2 mutations might provide an additional tool to better identify FGMM which are probably good candidates for adjuvant therapies.Citation
Gaudy-Marqueste C, Macagno N, Loundou A, Pellegrino E, Ouafik L, Budden T, et al. Molecular characterization of fast-growing melanomas. Journal of the American Academy of Dermatology. 2021 Jul.Journal
Journal of the American Academy of DermatologyDOI
10.1016/j.jaad.2021.07.011PubMed ID
34280484Additional Links
https://dx.doi.org/10.1016/j.jaad.2021.07.011Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.jaad.2021.07.011
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