Mundra, Piyashkumar A
Cook, Martin G
Grob, J. J.
AffiliationAix Marseille Univ, APHM, CRCM Inserm U1068, CNRS U7258, CHU Timone, Dermatology and Skin Cancer Department, Marseille, France.
MetadataShow full item record
AbstractBackground: The rate of growth of primary melanoma is a robust predictor of aggressiveness, but the mutational profile of fast-growing melanomas (FGMM), and its potential to stratify patients at high risk of death, has not been comprehensively studied. Objective: To investigate the epidemiological, clinical and mutational profile of primary cutaneous melanomas with a thickness ≥ 1mm, stratified by rate of growth (ROG). Methods: Observational prospective study. Deep-targeted sequencing of 40 melanoma driver genes on formalin fixed, paraffin embedded primary melanoma samples. Comparison of FGMM (ROG >0.5mm/month) and non-FGMM (ROG≤0.5 mm/month). Results: Two hundred patients were enrolled among which 70 were FGMM. The relapse free survival was lower in the FGMM group (p=0.014). FGMM had a higher number of predicted deleterious mutations within the 40 genes than non-FGMM (p=0.033). Ulceration (p=0.032), thickness (p=0.006), lower sun exposure (p=0.049), and FGFR2 mutations (p=0.037) were significantly associated with fast growth. Limitations: Single-center study, cohort size, potential memory bias, number of investigated genes. Conclusion: Fast growth is linked to specific tumor biology and environmental factors. Ulceration, thickness and FGFR2 mutations associate with fast growth. Screening for FGFR2 mutations might provide an additional tool to better identify FGMM which are probably good candidates for adjuvant therapies.
CitationGaudy-Marqueste C, Macagno N, Loundou A, Pellegrino E, Ouafik L, Budden T, et al. Molecular characterization of fast-growing melanomas. Journal of the American Academy of Dermatology. 2021 Jul.
JournalJournal of the American Academy of Dermatology
TypeMeetings and Proceedings
- Primary tumour ulceration in cutaneous melanoma: its role on TNM stages.
- Authors: Tas F, Erturk K
- Issue date: 2021 Feb 8
- GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.
- Authors: Livingstone E, Zaremba A, Horn S, Ugurel S, Casalini B, Schlaak M, Hassel JC, Herbst R, Utikal JS, Weide B, Gutzmer R, Meier F, Koelsche C, Hadaschik E, Sucker A, Reis H, Merkelbach-Bruse S, Siewert M, Sahm F, von Deimling A, Cosgarea I, Zimmer L, Schadendorf D, Schilling B, Griewank KG
- Issue date: 2020 Nov
- Aberrant DNA methylation is associated with aggressive clinicopathological features and poor survival in cutaneous melanoma.
- Authors: de Unamuno Bustos B, Murria Estal R, Pérez Simó G, Simarro Farinos J, Pujol Marco C, Navarro Mira M, Alegre de Miquel V, Ballester Sánchez R, Sabater Marco V, Llavador Ros M, Palanca Suela S, Botella Estrada R
- Issue date: 2018 Aug
- Characterizations of Gene Alterations in Melanoma Patients from Chinese Population.
- Authors: Luo Y, Zhang Z, Liu J, Li L, Xu X, Yao X, Dai Z, Wang X, Yang S, Wu H, Bu J, Wu Y, Xiang T, Li X
- Issue date: 2020
- Mutational dichotomy in desmoplastic malignant melanoma corroborated by multigene panel analysis.
- Authors: Jahn SW, Kashofer K, Halbwedl I, Winter G, El-Shabrawi-Caelen L, Mentzel T, Hoefler G, Liegl-Atzwanger B
- Issue date: 2015 Jul