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    Cutaneous soft tissue sarcomas: survival-related factors

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    Authors
    Gkantaifi, A.
    Diamantis, A.
    Mauri, D.
    Nixon, I.
    Kyriazoglou, A.
    Baloyiannis, I.
    Tsoukalas, N.
    Charalampakis, N.
    Schizas, D.
    Cuccia, F.
    Alongi, F.
    de Mello, R. A.
    Iliadis, G.
    Kamposioras, Konstantinos
    Mazonakis, M
    Tolia, M.
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    Affiliation
    Radiotherapy Department, Theagenio Anticancer Hospital of Thessaloniki, Thessaloniki, Greece.
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Cutaneous sarcomas are a heterogeneous group of rare mesenchymal neoplasms representing less than 1% of malignant tumors. Histology report remains the cornerstone for the diagnosis of these tumors. The most important clinicopathologic parameters related to prognosis include larger tumor size, high mitotic index, head and neck location, p53 mutations, depth of infiltration and histological grade, vascular and perineural invasion as well as the surgical margins status. Applying advanced biopsy techniques might offer more precise assessment of surgical margins, which constitutes a significant precondition for the management of these tumors. The management of cutaneous soft tissue sarcomas requires a multidisciplinary approach. Surgery remains the standard treatment, nonetheless adjuvant therapy may be required, consisting of radiotherapy, chemotherapy, and molecular targeted therapies to improve treatment outcomes. The role of molecular profiling in the treatment of uncontrolled disease is promising, but it may be offered to a relatively small proportion of patients and its use is still considered experimental in this setting. Due to the rarity of the disease, there is a need for knowledge and experience to be shared, pooled, organized and rationalized so that recent developments in medical science can have a major impact on the disease course. Multicenter clinical trials are needed to improve the care of patients with cutaneous sarcomas.
    Citation
    Gkantaifi A, Diamantis A, Mauri D, Nixon I, Kyriazoglou A, Baloyiannis I, et al. Cutaneous soft tissue sarcomas: survival-related factors. Arch Dermatol Res. 2021 Jul 17.
    Journal
    Archives of Dermatological Research
    URI
    http://hdl.handle.net/10541/624479
    DOI
    10.1007/s00403-021-02268-1
    PubMed ID
    34272971
    Additional Links
    https://dx.doi.org/10.1007/s00403-021-02268-1
    Type
    Other
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00403-021-02268-1
    Scopus Count
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