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    Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors

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    Authors
    Switzer, B.
    Haanen, J.
    Lorigan, Paul C
    Puzanov, I
    Turajlic, S.
    Affiliation
    Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    The clinical and immunologic implications of the SARS-CoV-2 pandemic for patients with cancer receiving systemic anticancer therapy have introduced a multitude of clinical challenges and academic controversies. This review summarizes the current evidence, discussion points, and recommendations regarding the use of immune checkpoint inhibitors (ICIs) in patients with cancer during the SARS-CoV-2 pandemic, with a focus on patients with melanoma and renal cell carcinoma (RCC). More specifically, we summarize the theoretical concepts and available objective data regarding the relationships between ICIs and the antiviral immune response, along with recommended clinical approaches to the management of melanoma and RCC patient cohorts receiving ICIs throughout the course of the COVID-19 pandemic. Additional insights regarding the use of ICIs in the setting of current and upcoming COVID-19 vaccines and broader implications toward future pandemics are also discussed.
    Citation
    Switzer B, Haanen J, Lorigan PC, Puzanov I, Turajlic S. Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors. J Immunother Cancer. 2021 Jul;9(7):e002835.
    Journal
    Journal for Immunotherapy of Cancer
    URI
    http://hdl.handle.net/10541/624478
    DOI
    10.1136/jitc-2021-002835
    PubMed ID
    34272309
    Additional Links
    https://dx.doi.org/10.1136/jitc-2021-002835
    Type
    Other
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1136/jitc-2021-002835
    Scopus Count
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