Show simple item record

dc.contributor.authorHutton, Colin
dc.contributor.authorHeider, Felix
dc.contributor.authorBlanco-Gomez, Adrian
dc.contributor.authorBanyard, Antonia
dc.contributor.authorKononov, Alexander
dc.contributor.authorZhang, Xiaohong
dc.contributor.authorKarim, S.
dc.contributor.authorPaulus-Hock, V.
dc.contributor.authorWatt, D.
dc.contributor.authorSteele, N.
dc.contributor.authorKemp, S.
dc.contributor.authorHogg, Elizabeth K. J.
dc.contributor.authorKelly, Joanna
dc.contributor.authorJackstadt, R. F.
dc.contributor.authorLopes, Filipa
dc.contributor.authorMenotti, Matteo
dc.contributor.authorChisholm, Luke
dc.contributor.authorLamarca, Angela
dc.contributor.authorValle, Juan W
dc.contributor.authorSansom, O. J.
dc.contributor.authorSpringer, Caroline
dc.contributor.authorMalliri, Angeliki
dc.contributor.authorMarais, Richard
dc.contributor.authorPasca di Magliano, M.
dc.contributor.authorZelenay, Santiago
dc.contributor.authorMorton, J. P
dc.contributor.authorJørgensen, Claus
dc.date.accessioned2021-08-17T12:22:37Z
dc.date.available2021-08-17T12:22:37Z
dc.date.issued2021en
dc.identifier.citationHutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021 Jul.en
dc.identifier.pmid34297917en
dc.identifier.doi10.1016/j.ccell.2021.06.017en
dc.identifier.urihttp://hdl.handle.net/10541/624413
dc.description.abstractFibroblasts display extensive transcriptional heterogeneity, yet functional annotation and characterization of their heterocellular relationships remains incomplete. Using mass cytometry, we chart the stromal composition of 18 murine tissues and 5 spontaneous tumor models, with an emphasis on mesenchymal phenotypes. This analysis reveals extensive stromal heterogeneity across tissues and tumors, and identifies coordinated relationships between mesenchymal and immune cell subsets in pancreatic ductal adenocarcinoma. Expression of CD105 demarks two stable and functionally distinct pancreatic fibroblast lineages, which are also identified in murine and human healthy tissues and tumors. Whereas CD105-positive pancreatic fibroblasts are permissive for tumor growth in vivo, CD105-negative fibroblasts are highly tumor suppressive. This restrictive effect is entirely dependent on functional adaptive immunity. Collectively, these results reveal two functionally distinct pancreatic fibroblast lineages and highlight the importance of mesenchymal and immune cell interactions in restricting tumor growth.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.ccell.2021.06.017en
dc.titleSingle-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunityen
dc.typeArticleen
dc.contributor.departmentSystems Oncology, Cancer Research UK Manchester Institute, Alderley Park, Manchester SK10 4TG,en
dc.identifier.journalCancer Cellen
dc.description.noteen]
refterms.dateFOA2021-08-18T09:03:46Z


Files in this item

Thumbnail
Name:
34297917.pdf
Size:
10.57Mb
Format:
PDF
Description:
From UNPAYWALL

This item appears in the following Collection(s)

Show simple item record