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dc.contributor.authorAdam, Safwaan
dc.contributor.authorHo, Jan Hoong
dc.contributor.authorBashir, B.
dc.contributor.authorIqbal, Z.
dc.contributor.authorFerdousi, M.
dc.contributor.authorSyed, A. A
dc.contributor.authorSoran, H.
dc.date.accessioned2021-07-28T12:41:55Z
dc.date.available2021-07-28T12:41:55Z
dc.date.issued2021en
dc.identifier.citationAdam S, Ho JH, Bashir B, Iqbal Z, Ferdousi M, Syed AA, et al. The impact of atherosclerotic cardiovascular disease, dyslipidaemia and lipid lowering therapy on Coronavirus disease 2019 outcomes: an examination of the available evidence. Current Opinion in Lipidology . 2021 Jun 9;32(4):231–43.en
dc.identifier.pmid34116544en
dc.identifier.doi10.1097/mol.0000000000000763en
dc.identifier.urihttp://hdl.handle.net/10541/624252
dc.description.abstractPurpose of review: Coronavirus Disease 2019 (COVID19) has caused significant global morbidity and mortality, especially in persons with underlying cardiovascular disease. There have been concerns that lipid-lowering therapy (LLT) increases angiotensin-converting enzyme 2 levels. Conversely, pleiotropic effects of statins can theoretically protect against severe COVID19 infection, supporting evidence from other respiratory illnesses in which statin use probably confers benefit. Recent findings: There is an abundance of studies that show that statins are safe and potentially protect against severe COVID19 infection (critical illness and death), even when adjustment for potential confounders is undertaken. However, the evidence is limited to retrospective cohorts. The benefit for patients with diabetes is less clear. There is a paucity of evidence for other LLT agents. Available clinical guidelines recommend the ongoing use of LLT in patients with COVID19 (unless specifically contra-indicated) and the data from available studies support these. Summary: In patients with COVID19 infection, LLT should be continued. However, the current findings need substantiating in larger prospective clinical studies with specific examination of the possible mechanisms by which LLT confers benefit from COVID19.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1097/mol.0000000000000763en
dc.titleThe impact of atherosclerotic cardiovascular disease, dyslipidaemia and lipid lowering therapy on Coronavirus disease 2019 outcomes: an examination of the available evidenceen
dc.typeOtheren
dc.contributor.departmentThe University of Manchester, Faculty of Biology, Medicine and Health Department of Endocrinologyen
dc.identifier.journalCurrent Opinion in Lipidologyen
dc.description.noteen]


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