• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    A real-world analysis of 30-day post systemic anti-cancer therapy mortality in patients with small cell lung cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Carter, Louise
    Church, Matt
    Blackhall, Fiona H
    Affiliation
    The Christie NHS Foundation Trust, Manchester
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Introduction: Small cell lung cancer (SCLC) is highly aggressive with a poor prognosis. Chemo-immunotherapy is recommended as first-line treatment in patients of good performance status and has excellent response rates. However, patients frequently present late or with oncological emergencies such as superior vena cava obstruction (SVCO) where benefits of systemic anti-cancer therapy (SACT) are less clear. This study aimed to evaluate SCLC patients who died within 30 days of SACT administration to better understand this at-risk patient group. Methods: Patients with SCLC who died within 30 days of receiving SACT between August 2012 and September 2019 at the Christie Hospital, UK, were characterised for demographics, oncological history, clinical features and cause of death. A comparator cohort of patients who did not die within 30 days was randomly generated from health records and analysed for statistical differences and multivariate post-SACT survival. Results: There were 105 SCLC patients who died within 30 days of SACT. The majority were elderly and 81% were performance status 2 or 3 (Table 1). SVCO was present in 25%, 82% of patients were receiving first-line SACT, 42% received single-agent carboplatin and 38% died within ten days of SACT. Cause of death was determined to be progressive disease in 63% and neutropenic sepsis in 9.5%, with 28.6% possibly related to SACT. Comparison with 95 comparator patients showed significantly higher SVCO (p=0.01) and performance status (p<0.001) in the 30-day mortality cohort. Higher performance status, raised leukocytes and low serum sodium were associated with lower 30-day post-SACT survival on multivariate analysis (hazard ratio 1.77, 1.08, 0.96 respectively). Conclusions: International guidelines support combination SACT in SCLC patients of good performance status, but nuances remain regarding optimal SACT for frailer patients. These results highlight the high risk of 30-day post-SACT mortality in SCLC, particularly in those with markers of poor prognosis.
    Citation
    Carter L, Church M, Blackhall F. A real-world analysis of 30-day post systemic anti-cancer therapy mortality in patients with small cell lung cancer. Lung Cancer . 2021 Jun;156:S65. 
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/624223
    Type
    Meetings and Proceedings
    Language
    en
    Collections
    All Christie Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.