• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Real world outcomes in patients with lung oligometastases treated with SABR - a single-centre experience

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Fatimilehin, Abiola
    Bewley, Michelle
    Bowen Jones, Sarah
    Chan, Clara
    Coote, Joanna H
    Harris, Catherine
    Harris, Maggie A
    Pemberton, Laura S
    Salem, Ahmed
    Sheikh, Hamid Y
    Turpin, Zoe
    Whitehurst, Philip
    Wooder, Rachael
    Faivre-Finn, Corinne
    Bayman, Neil A
    Woolf, David K
    Show allShow less
    Affiliation
    The Christie NHS Foundation Trust, Manchester,
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Introduction: Delivering Stereotactic Ablative Body Radiotherapy (SABR) to patients with extracranial oligometastatic disease has the potential to improve long-term disease control, survival and defer changes to systemic therapies [1]. We present the results from an audit of patients treated with SABR under the NHS Commissioning through Evaluation (CtE) scheme at The Christie Hospital, Manchester UK. Methods: The outcomes of patients who received SABR to lung lesions or thoracic nodes under CtE were analysed. Prescribed doses included 30-60Gy in 3-8 fractions to nodes and 54-60 Gy in 3-8 fractions to lung lesions. Patients were eligible if aged ≥18, had ≤3 metastatic lesions, WHO performance status of ≤2, onset of metastatic disease was ≥6 months from the primary tumour diagnosis and life expectancy estimated to be ≥6 months. The main outcomes evaluated included local control (assessed by local radiologists) and overall survival which were obtained from hospital records. Adverse events by CTCAE grade were recorded prospectively. Results: 52 patients treated between February 2016 and August 2019 were included. Median follow up was 28.5 months and median age was 72 (range 49-90 years). 51.9% were female and 75% had a performance status of 0-1. The most common primary was colorectal (n=23; (44.2%)). 5 patients received SABR to thoracic nodes, and 8 patients had >1 lesion treated. The median BED10 dose was 121 Gy. Local control was 96% at 1 year and 84.6% at 2 years. Overall survival was 94.2% at 1 year and 89.7% at 2 years. One patient had a toxicity graded ≥3, which was fatigue. Conclusion: The findings demonstrate high levels of local control and overall survival in these patients, with low rates of toxicity. Our findings are comparable to the overall national results, and SABR to oligometastatic lesions has now been commissioned.
    Citation
    Fatimilehin A, Bewley M, Bowen Jones S, Chan C, Coote J, Harris C, et al. Real world outcomes in patients with lung oligometastases treated with SABR – a single-centre experience. Lung Cancer . 2021 Jun;156:S58–9.
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/624221
    Type
    Meetings and Proceedings
    Language
    en
    Collections
    All Christie Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.