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dc.contributor.authorLagopati, N.
dc.contributor.authorKotsinas, A.
dc.contributor.authorVeroutis, D.
dc.contributor.authorEvangelou, K.
dc.contributor.authorPapaspyropoulos, A.
dc.contributor.authorArfanis, M.
dc.contributor.authorFalaras, P.
dc.contributor.authorKitsiou, P. V.
dc.contributor.authorPateras, I.
dc.contributor.authorBergonzini, A.
dc.contributor.authorFrisan, T.
dc.contributor.authorKyriazis, S.
dc.contributor.authorTsoukleris, D. S.
dc.contributor.authorTsilibary, E. C.
dc.contributor.authorGazouli, M.
dc.contributor.authorPavlatou, E. A
dc.contributor.authorGorgoulis, Vassilis G
dc.date.accessioned2021-07-19T10:28:54Z
dc.date.available2021-07-19T10:28:54Z
dc.date.issued2021en
dc.identifier.citationLAGOPATI N, KOTSINAS A, VEROUTIS D, EVANGELOU K, PAPASPYROPOULOS A, ARFANIS M, et al. Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer. Cancer Genomics Proteomics. 2021;18(3 Suppl):425–39.en
dc.identifier.pmid33994365en
dc.identifier.doi10.21873/cgp.20269en
dc.identifier.urihttp://hdl.handle.net/10541/624136
dc.description.abstractBackground/aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential. Materials and methods: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and conclusion: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.21873/cgp.20269en
dc.titleBiological effect of silver-modified nanostructured titanium dioxide in canceren
dc.typeArticleen
dc.contributor.departmentLaboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece.en
dc.identifier.journalCancer Genomics Proteomicsen
dc.description.noteen]
refterms.dateFOA2021-07-26T10:25:57Z


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