Biological effect of silver-modified nanostructured titanium dioxide in cancer
Kitsiou, P. V.
Tsoukleris, D. S.
Tsilibary, E. C.
Pavlatou, E. A
Gorgoulis, Vassilis G
AffiliationLaboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
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AbstractBackground/aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential. Materials and methods: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and conclusion: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.
CitationLAGOPATI N, KOTSINAS A, VEROUTIS D, EVANGELOU K, PAPASPYROPOULOS A, ARFANIS M, et al. Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer. Cancer Genomics Proteomics. 2021;18(3 Suppl):425–39.
JournalCancer Genomics Proteomics
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