Show simple item record

dc.contributor.authorChemi, Francesca
dc.contributor.authorMohan, Sumitra
dc.contributor.authorGuevara, Tatiana
dc.contributor.authorClipson, Alexandra
dc.contributor.authorRothwell, Dominic G
dc.contributor.authorDive, Caroline
dc.date.accessioned2021-07-19T10:28:53Z
dc.date.available2021-07-19T10:28:53Z
dc.date.issued2021en
dc.identifier.citationChemi F, Mohan S, Guevara T, Clipson A, Rothwell DG, Dive C. Early Dissemination of Circulating Tumor Cells: Biological and Clinical Insights. Front Oncol. 2021 May 7;11.en
dc.identifier.pmid34026650en
dc.identifier.doi10.3389/fonc.2021.672195en
dc.identifier.urihttp://hdl.handle.net/10541/624135
dc.description.abstractCirculating tumor cells (CTCs) play a causal role in the development of metastasis, the major cause of cancer-associated mortality worldwide. In the past decade, the development of powerful cellular and molecular technologies has led to a better understanding of the molecular characteristics and timing of dissemination of CTCs during cancer progression. For instance, genotypic and phenotypic characterization of CTCs, at the single cell level, has shown that CTCs are heterogenous, disseminate early and could represent only a minor subpopulation of the primary tumor responsible for disease relapse. While the impact of molecular profiling of CTCs has not yet been translated to the clinic, CTC enumeration has been widely used as a prognostic biomarker to monitor treatment response and to predict disease relapse. However, previous studies have revealed a major challenge: the low abundance of CTCs in the bloodstream of patients with cancer, especially in early stage disease where the identification and characterization of subsequently "lethal" cells has potentially the greatest clinical relevance. The CTC field is rapidly evolving with development of new technologies to improve the sensitivity of CTC detection, enumeration, isolation, and molecular profiling. Here we examine the technical and analytical validity of CTC technologies, we summarize current data on the biology of CTCs that disseminate early and review CTC-based clinical applications.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.3389/fonc.2021.672195en
dc.titleEarly dissemination of circulating tumor cells: biological and clinical insightsen
dc.typeOtheren
dc.contributor.departmentCancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester, Macclesfield, United Kingdom.en
dc.identifier.journalFrontiers in Oncologyen
dc.description.noteen]
refterms.dateFOA2021-07-26T11:50:53Z


Files in this item

Thumbnail
Name:
34026650.pdf
Size:
875.6Kb
Format:
PDF
Description:
From UNPAYWALL

This item appears in the following Collection(s)

Show simple item record