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    High variability in anatomic patterns of cutaneous photodamage: a population-based study

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    Authors
    Betz-Stablein, B.
    Llewellyn, S.
    Bearzi, P.
    Grochulska, K.
    Rutjes, C.
    Aitken, J. F.
    Janda, M.
    O'Rouke, P.
    Soyer, H. P
    Green, Adèle C
    Affiliation
    Cancer and Population Studies, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Background: Skin cancer is strongly associated with photodamaged skin, but body sites are often referred to as 'exposed' or 'unexposed' to sun without recognizing extent of site-specific variation. Objectives: To assess whole-body patterns of photodamage in an Australian population. Methods: A random sample of adult residents of Queensland underwent imaging across 10 body sites. Photodamage was graded from images using an ordinal photonumeric scale. We used cluster analysis to identify whole-body photodamage patterns and prevalence proportion ratios (PPRs) to assess associated factors. Results: Of 190 adults (median age 52; 58% males), 58% showed severe or moderate-to-severe photodamage on most body sites. A higher proportion of woman had severe photodamage on the arms (upper: P = 0.002, lower: P = 0.034). A higher proportion of men had moderate or severe photodamage on the lower back (P = 0.004). We identified four photodamage patterns: 'severe general' (n = 24, 13%), 'moderate-severe general' (n = 86, 45%), 'moderate-severe v-neck' (n = 40, 21%) and 'mild-moderate upper body' (n = 12, 6%). All participants with 'severe-general' photodamage were >50 years and more likely to have past skin cancer (PPR: 2.54, 95% CI: 1.44-4.49) than those with 'moderate-severe v-neck' photodamage. Those with 'moderate-severe general' photodamage showed similar associations and were more likely female (PPR: 1.33, 95% CI: 1.04-1.69). Past or current smoking was associated with having higher levels of photodamage, with no smokers in those with 'mild-moderate upper body' photodamage. Conclusions: Moderate-to-severe photodamage across much of the body is common in Queensland adults and associated with age, sex, past skin cancer and smoking. Assuming a universal pattern of site-specific sun exposure could lead to spurious correlations, while accurate and objective assessment of site-specific photodamage can add to understanding of the development of sun-associated skin cancers, in particular site-specific skin carcinogenesis. Additionally, degree of site-specific photodamage has the potential to assist skin cancer screening.
    Citation
    Betz-Stablein B, Llewellyn S, Bearzi P, Grochulska K, Rutjes C, Aitken JF, et al. High variability in anatomic patterns of cutaneous photodamage: a population-based study. J Eur Acad Dermatol Venereol. 2021 Jun 9.
    Journal
    Journal of the European Academy of Dermatology and Venereology
    URI
    http://hdl.handle.net/10541/624127
    DOI
    10.1111/jdv.17352
    PubMed ID
    33991136
    Additional Links
    https://dx.doi.org/10.1111/jdv.17352
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1111/jdv.17352
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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