Show simple item record

dc.contributor.authorBudden, Timothy
dc.contributor.authorGaudy-Marqueste, C.
dc.contributor.authorPorter, Andrew P
dc.contributor.authorKay, E.
dc.contributor.authorGurung, Shilpa
dc.contributor.authorEarnshaw, Charles
dc.contributor.authorRoeck, K.
dc.contributor.authorCraig, S.
dc.contributor.authorTraves, V.
dc.contributor.authorKrutmann, J.
dc.contributor.authorMuller, Patricia
dc.contributor.authorMotta, L.
dc.contributor.authorZanivan, S.
dc.contributor.authorMalliri, A.
dc.contributor.authorFurney, S. J.
dc.contributor.authorNagore, E
dc.contributor.authorVirós, Amaya
dc.date.accessioned2021-07-19T10:28:52Z
dc.date.available2021-07-19T10:28:52Z
dc.date.issued2021en
dc.identifier.citationBudden T, Gaudy-Marqueste C, Porter A, Kay E, Gurung S, Earnshaw CH, et al. Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nat Commun. 2021 May 12;12(1).en
dc.identifier.pmid33980846en
dc.identifier.doi10.1038/s41467-021-22953-zen
dc.identifier.urihttp://hdl.handle.net/10541/624125
dc.description.abstractUltraviolet radiation (UVR) damages the dermis and fibroblasts; and increases melanoma incidence. Fibroblasts and their matrix contribute to cancer, so we studied how UVR modifies dermal fibroblast function, the extracellular matrix (ECM) and melanoma invasion. We confirmed UVR-damaged fibroblasts persistently upregulate collagen-cleaving matrix metalloprotein-1 (MMP1) expression, reducing local collagen (COL1A1), and COL1A1 degradation by MMP1 decreased melanoma invasion. Conversely, inhibiting ECM degradation and MMP1 expression restored melanoma invasion. Primary cutaneous melanomas of aged humans show more cancer cells invade as single cells at the invasive front of melanomas expressing and depositing more collagen, and collagen and single melanoma cell invasion are robust predictors of poor melanoma-specific survival. Thus, primary melanomas arising over collagen-degraded skin are less invasive, and reduced invasion improves survival. However, melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis. Finally, high COL1A1 gene expression is a biomarker of poor outcome across a range of primary cancers.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41467-021-22953-zen
dc.titleUltraviolet light-induced collagen degradation inhibits melanoma invasionen
dc.typeArticleen
dc.contributor.departmentSkin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UKen
dc.identifier.journalNature Communicationsen
dc.description.noteen]
refterms.dateFOA2021-07-26T10:17:18Z


Files in this item

Thumbnail
Name:
33980846.pdf
Size:
5.767Mb
Format:
PDF
Description:
FROM CORE

This item appears in the following Collection(s)

Show simple item record