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dc.contributor.authorIssa, Allaudin
dc.contributor.authorSebro, K.
dc.contributor.authorKwok, A.
dc.contributor.authorJanisch, F.
dc.contributor.authorGrossmann, N. C.
dc.contributor.authorLee, Esther
dc.contributor.authorLucky, M.
dc.contributor.authorOliveira, Pedro
dc.contributor.authorLau, Maurice W
dc.contributor.authorParnham, Arie S
dc.contributor.authorSangar, Vijay K
dc.contributor.authorFankhauser, Christian D
dc.date.accessioned2021-07-19T10:28:50Z
dc.date.available2021-07-19T10:28:50Z
dc.date.issued2021en
dc.identifier.citationIssa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, et al. Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review. European Urology Focus. 2021 May.en
dc.identifier.pmid33994168en
dc.identifier.doi10.1016/j.euf.2021.04.026en
dc.identifier.urihttp://hdl.handle.net/10541/624113
dc.description.abstractPenile intraepithelial neoplasia (PeIN) is a rare skin condition with potential to progress to invasive penile cancer. We performed a systematic review of treatment options and outcomes for PeIN. Topical agents showed response and recurrence rates of 40-100% and 20% for imiquimod, and 48-74% and 11% for 5-fluorouracil, respectively. Discontinuation of topical agents because of side effects was observed in 12% of cases. Response rates for laser therapies were 52-100%, with recurrence in 7-48% of cases and a change in penile sensitivity in 50%. Circumcision cleared preputial PeIN. Rates of recurrence after surgical treatment of glans PeIN were 25% for wide local excision, 4% for Mohs surgery, 5% for total glans resurfacing, and 10% for glansectomy. There are limited data on factors predictive of treatment response and on sequencing of treatment options. PATIENT SUMMARY: Several treatment options are available for men with precancerous lesions of the foreskin or glans. Close follow-up is necessary as lesions can recur or progress to invasive penile cancer.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.euf.2021.04.026en
dc.titleTreatment options and outcomes for men with penile intraepithelial neoplasia: a systematic reviewen
dc.typeOtheren
dc.contributor.departmentDepartment of Urology, The Christie NHS Foundation Trust, Manchesteen
dc.identifier.journalEuropean Urology Focusen
dc.description.noteen]


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