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dc.contributor.authorStubbs, M.
dc.contributor.authorClark, V.
dc.contributor.authorGibson, P.
dc.contributor.authorYorke, J
dc.contributor.authorMcDonald, V.
dc.date.accessioned2021-07-19T10:28:40Z
dc.date.available2021-07-19T10:28:40Z
dc.date.issued2021en
dc.identifier.citationStubbs M, Clark V, Gibson P, Yorke J, McDonald V. Anxiety and depression in severe asthma. Respirology. 2021;26:130.en
dc.identifier.urihttp://hdl.handle.net/10541/624069
dc.description.abstractIntroduction/Aim: Symptoms of anxiety and depression are highly prevalent in people with severe asthma. We aim ed to determine clinical characteristics associated with co-existing symptoms of anxiety and/or depression in adults with severe asthma. Methods: Participants with severe asthma (N=140) were recruited to a cross-sectional study. Asthma quality-of-life and control were assessed using the Asthma Quality of Life Questionnaire (AQLQ) and the Asthma Control Questionnaire. Dyspnoea was assessed using the MMRC scale, dysfunctional breathing with the Nijmegen Questionnaire and symptoms with the Hospital Anxiety and De pression Scale (HADS). Clinical charac- teristics were compared between three subgroups: severe asthma only, severe asthma with anxiety or depression and, severe asthma with both (indicated by HADS sub-scores [<8 on both subscales; 8 on one sub- scale; 8 on both subscales]). Associations of clinical characteristics and symptoms of anxiety and/or depression were determined using multivari- ate logistic regression. Results: Participants were (Mean+/-SD) 59.3+/-14.7 years old, and 62% female. There were 74 (53%) severe asthma participants without symp- toms of anxiety or depression, 48 (34%) with symptoms of anxiety or depression and 18 (13%) with overlapping symptoms. Asthma QoL impairment was greater in participants with anxiety or depressive symp- toms (4.5+/-1.3) and overlapping symptoms (4.3+/-1.2), compared to severe asthma only (5.2+/-1.1, p=0.0005). Asthma control was significantly worse in the anxiety or depression group (2.7+/-1.1) compared to the overlapping symptom group (2.6+/-1.0) and severe asthma only (2.0+/-0.9, p=0.001). In multivariate models, dyspnoea was significantly associated with symp- toms of anxiety or depression (OR=1.63 [1.02, 2.59]). Dysfunctional breathing (OR=1.15 [1.04, 1.23]) and obesity (OR=1.17 [1.00, 1.35]) were significantly associated with symptoms of overlapping anxiety and depression. Conclusion: People with severe asthma and anxiety and/or depres- sive symptoms have poorer HRQoL and asthma control. Dyspnoea, dys- functional breathing and obesity are associated with these symptoms. These data support the need for psychological screening as part of multi- dimensional assessment in severe asthmaen
dc.language.isoenen
dc.titleAnxiety and depression in severe asthmaen
dc.typeMeetings and Proceedingsen
dc.contributor.departmentNational Health and Medical Research Council Centre for Research Excellence in Severe Asthma, The University of Newcastle, Newcastle,en
dc.identifier.journalRespirologyen
dc.description.noteen]


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