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    Associations of specific-age and decade recall body mass index trajectories with obesity-related cancer

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    Authors
    Watson, Charlotte
    Renehan, Andrew G
    Geifman, N.
    Affiliation
    Manchester Cancer Research Centre and NIHR Manchester Biomedical Research Centre, Manchester, UK.
    Issue Date
    2021
    
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    Abstract
    Background: Excess body fatness, commonly approximated by a one-off determination of body mass index (BMI), is associated with increased risk of at least 13 cancers. Modelling of longitudinal BMI data may be more informative for incident cancer associations, e.g. using latent class trajectory modelling (LCTM) may offer advantages in capturing changes in patterns with time. Here, we evaluated the variation in cancer risk with LCTMs using specific age recall versus decade recall BMI. Methods: We obtained BMI profiles for participants from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We developed gender-specific LCTMs using recall data from specific ages 20 and 50 years (72,513 M; 74,837 W); decade data from 30s to 70s (42,113 M; 47,352 W) and a combination of both (74,106 M, 76,245 W). Using an established methodological framework, we tested 1:7 classes for linear, quadratic, cubic and natural spline shapes, and modelled associations for obesity-related cancer (ORC) incidence using LCTM class membership. Results: Different models were selected depending on the data type used. In specific age recall trajectories, only the two heaviest classes were associated with increased risk of ORC. For the decade recall data, the shapes appeared skewed by outliers in the heavier classes but an increase in ORC risk was observed. In the combined models, at older ages the BMI values were more extreme. Conclusions: Specific age recall models supported the existing literature changes in BMI over time are associated with increased ORC risk. Modelling of decade recall data might yield spurious associations.
    Citation
    Watson C, Renehan AG, Geifman N. Associations of specific-age and decade recall body mass index trajectories with obesity-related cancer. BMC Cancer. 2021 May 5;21(1).
    Journal
    BMC Cancer
    URI
    http://hdl.handle.net/10541/624062
    DOI
    10.1186/s12885-021-08226-4
    PubMed ID
    33952200
    Additional Links
    https://dx.doi.org/10.1186/s12885-021-08226-4
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12885-021-08226-4
    Scopus Count
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